{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:10:59Z","timestamp":1790424659150,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The role of the infrapatellar fat pad (IPFP) in knee osteoarthritis is not understood. This study aimed to identify relationships between MRI\u2010based signal abnormalities in the IPFP and measures of structural pathology and symptom severity in PFJOA, as well as investigate the influence of obesity and sex on these relationships. Seventy participants (ages 28\u201380) with isolated PFJOA underwent bilateral knee MRI scan acquisitions and completed the Knee Injury and Osteoarthritis Outcome Score (KOOS). MR images were scored for abnormal IPFP area and signal intensity, joint effusion, synovial proliferation, and patellar and trochlear cartilage damage. Repeated measures correlations were performed to assess associations between abnormal area and signal of IPFP and PFJOA pathology and KOOS, respectively. Associations were interrogated across weight\u2010based groups based on BMI and sex\u2010based groups. Between abnormal IPFP and PFJOA pathology, we observed no significant associations. Between abnormal IPFP and patient\u2010reported outcomes, we observed weak to moderate significant negative associations between the size of the abnormal IPFP area and all KOOS subscales. In a sex\u2010based analysis of IPFP and KOOS associations, we observed significant moderate negative correlations between IPFP and KOOS scores across all subcategories in female participants. In male participants, abnormal IPFP was not associated with KOOS scores. The IPFP is significantly related to PFJOA patient\u2010reported pain and function, and this correlation is stronger in high\u2010risk OA groups.\u00a0<\/jats:p>","DOI":"10.1002\/jor.26048","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T22:23:42Z","timestamp":1737411822000},"page":"770-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationships Between the Infrapatellar Fat Pad and Patellofemoral Joint Osteoarthritis Differ With Body Mass Index and Sex"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4603-0519","authenticated-orcid":false,"given":"J. 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Ko et al. \u201cAssociation of General and Central Obesity and Their Changes With Risk of Knee Osteoarthritis: A Nationwide Population\u2010Based Cohort Study \u201dScientific Reports accessed August 30 2024 https:\/\/www.nature.com\/articles\/s41598-023-30727-4."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40102"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.1116"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.09.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300100982"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex287"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.03.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.02.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2024.09.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2537811"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21414"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.09.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.03.006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096776"},{"key":"e_1_2_7_28_1","unstructured":"pythonTM Welcome to Python.org 2024 https:\/\/www.python.org\/."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00456"},{"issue":"2","key":"e_1_2_7_30_1","first-page":"51S","article-title":"National Institutes of Health","volume":"6","author":"Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults\u2014The Evidence Report","year":"1998","journal-title":"Obesity Research"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22712"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.014"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.06.030"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.05.015"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405619666230310093402"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/10225536221092215"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-024-00159-z"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","unstructured":"M. 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Burton et al. \u201cRemoval of the Infrapatellar Fat Pad and Associated Synovium Benefits Female Guinea Pigs in the Dunkin Hartley Model of Idiopathic Osteoarthritis \u201dAnnals of Translational Medicine accessed September 5 2024 https:\/\/atm.amegroups.org\/article\/view\/125191\/html.","DOI":"10.21037\/atm-23-1886"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.02.789"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041331"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph21060757"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.26048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T05:46:18Z","timestamp":1765777578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.26048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jor.26048"],"URL":"https:\/\/doi.org\/10.1002\/jor.26048","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"2024-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}