{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:33:03Z","timestamp":1784691183573,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The primary purpose of this study was to determine the preoperative predictors of gait biomechanics 6 months after unilateral total knee arthroplasty (TKA). There were 126 participants (age 64.4\u2009\u00b1\u20097.1 years, 75 females) who underwent instrumented biomechanical assessments while walking at a self\u2010selected pace preoperatively, 10 weeks after (post\u2010rehabilitation), and 6 months after unilateral TKA. Outcomes were peak knee extension moment (pKEM), knee angle excursion, and vertical ground reaction force (vGRF) ratio (surgical\/contralateral). Potential clinical, demographic, and biomechanical predictors were tested univariately and considered a candidate for the final model if <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.15. Each multivariate model initially contained all candidates, and backward selection was used to determine the final model. Greater 6\u2010month surgical limb pKEM was predicted (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.31) by greater preoperative pKEM (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.44, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), better quadriceps activation (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.23, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), and male sex (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.21, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). Greater 6\u2010month surgical knee excursion was predicted (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.34) by greater preoperative excursion (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.39, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), male sex (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.28, <jats:italic>p<\/jats:italic>\u2009=\u20090.0007), and preoperative quadriceps strength (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.047). Six\u2010month vGRF ratio was predicted (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.16) by preoperative vGRF ratio (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.37, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and study treatment group (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.18, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Preoperative biomechanical variables at post\u2010rehabilitation were also the strongest predictors of 6\u2010month biomechanics.<\/jats:p><jats:p><jats:bold>Statement of Clinical Significance:<\/jats:bold> The strongest and most consistent predictor of gait biomechanics 6 months after TKA was the respective preoperative gait biomechanics variable, which may have important clinical implications for surgical decision making and prehabilitation\/rehabilitation strategies. Biofeedback targeting vGRF predicted vGRF symmetry, but no other gait parameters, suggesting targeted interventions are needed. Improving quadriceps strength and activation may also facilitate knee biomechanics.<\/jats:p>","DOI":"10.1002\/jor.70052","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:09:02Z","timestamp":1757416142000},"page":"1964-1972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative and Post\u2010Rehabilitation Predictors of Gait Biomechanics Six Months After Total Knee Arthroplasty"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-3700","authenticated-orcid":false,"given":"Jacob J.","family":"Capin","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Marquette University Milwaukee Wisconsin USA"},{"name":"Clinical &amp; Translational Science Institute of Southeast Wisconsin Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph 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