{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:17:00Z","timestamp":1762867020396,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Proper alignment between donor and recipient cartilage in osteochondral allograft transplantation supports tissue integration and the formation of a stable articulating surface. This study evaluated the use of patient\u2010specific 3D\u2010printed drill guides to improve alignment in an ovine model of osteochondral allograft transplantation when used in place of a free\u2010hand drilling technique. Fourteen female Arcott sheep underwent bilateral osteochondral allograft transplantation. Drill guides were used to transplant 51 grafts (6.5\u2009mm diameter), while the freehand drilling technique was used to transplant 32 grafts. After a 9\u2010month survival time, tissues were harvested. Cross\u2010sectional confocal microscopy images and histological sections were used to quantify height differences between donor and recipient tissues. Grafts transplanted with the drill guides showed significantly reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0005) height differences between donor and recipient tissues compared to the freehand drilling technique. However, the guide technique was associated with increased osteophyte development (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0180) and synovial inflammation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0451). These findings demonstrate that patient\u2010specific 3D\u2010printed drill guides improve graft alignment in an ovine model of osteochondral allograft transplantation. Methodological improvements are proposed to minimize osteophyte formation and inflammation in future studies.\n                  <\/jats:p>","DOI":"10.1002\/jor.70057","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T08:17:03Z","timestamp":1757233023000},"page":"2114-2124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient\u2010Specific 3D\u2010Printed Drill Guides for an Ovine Osteochondral Allograft Transplantation Model"],"prefix":"10.1002","volume":"43","author":[{"given":"R. Peter","family":"Suderman","sequence":"first","affiliation":[{"name":"Faulty of Applied Science and Engineering University of Toronto Toronto Canada"},{"name":"Kierans Janigan Biomechanics Research Program, Lunenfeld\u2010Tanenbaum Research Institute Sinai Health System Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark B.","family":"Hurtig","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory, Department of Clinical Studies University of Guelph Guelph Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc D.","family":"Grynpas","sequence":"additional","affiliation":[{"name":"Faulty of Applied Science and Engineering University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R. 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