{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:26Z","timestamp":1786978106218,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>High levels of physical activity or high BMI during puberty could negatively influence bone and cartilage development. Little is known about the effects of loading on patellar and femoral bone shape in a young population. Therefore, we aim to identify the association between 3D patella and femur shape and biomechanical loading in a young adolescent population. Participants were selected from an ongoing cohort study (Generation\u2010R study). Participants that underwent knee\u2010MRI at 13 years\u2010old follow\u2010up were included. Patellae and femora were segmented from these MRIs and using these 3D models, statistical shape modeling was performed. Generalized estimating equations were used to analyze the association between loading (BMI, physical activity and sports participation) and shape variation. Bonferroni correction was used to correct for multiple testing. 1912 participants underwent MRI of which 3638 patellae and 3355 femora were included in the statistical shape models. Nine patellar (modes 1\u20137, 10 and 11) and nine femoral (modes 1\u20133, 6\u201310 and 14) shape modes were associated with BMI. Sports participation at thirteen years old was associated with one patellar (mode 1) and two femoral (modes 1 and 6) shape modes. One shape mode (mode 12) was associated with sports participation at 9 and 13 years old. Sports participation and BMI were significantly associated with bone shape variations. BMI was associated with most shape variations found in our statistical shape models, emphasizing the significant impact of BMI on bone morphology during adolescence with implications for musculoskeletal health and injury prevention.<\/jats:p>","DOI":"10.1002\/jor.70089","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:48:53Z","timestamp":1761036533000},"page":"2221-2232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patellar and Femoral Bone Morphology Is Associated With Overweight and Sports Participation in Young Adolescents"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6578-1740","authenticated-orcid":false,"given":"Rosemarijn","family":"van Paassen","sequence":"first","affiliation":[{"name":"Erasmus MC Medical University Center Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazli","family":"Tumer","sequence":"additional","affiliation":[{"name":"Technical University Delft Delft Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9278-4719","authenticated-orcid":false,"given":"Jukka","family":"Hirvasniemi","sequence":"additional","affiliation":[{"name":"Erasmus MC Medical University Center Rotterdam Rotterdam Netherlands"},{"name":"Technical University Delft Delft Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom M.","family":"Piscaer","sequence":"additional","affiliation":[{"name":"Erasmus MC Medical University Center Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir.A.","family":"Zadpoor","sequence":"additional","affiliation":[{"name":"Technical University Delft Delft Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Klein","sequence":"additional","affiliation":[{"name":"Erasmus MC Medical University Center Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita M. 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