{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:06:50Z","timestamp":1779289610248,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    End\u2010stage arthritis of the hip, knee, or ankle leads to differential gait adaptations, but the differences in gait stability remain poorly understood. This study examined whether dynamic gait stability differed between patients with end\u2010stage hip arthritis (HA), knee arthritis (KA) and ankle arthritis (AA), and matched healthy controls (HC). Anteroposterior (AP) and mediolateral (ML) Margin of Stability (MoS) were determined at heel strike, contralateral toe\u2010off, and midstance during overground walking in 30 HA, 20 KA, 30 AA, and 30 HC participants. Data was analyzed using linear mixed\u2010effects models with gait speed included as a fixed effect and participant as a random effect. A significant interaction was found between group (HA, KA, AA, HC) and limb (arthritic, non\u2010arthritic) for every MoS variable (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). HA and AA exhibited greater arthritic limb ML MoS during single support (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and smaller non\u2010arthritic limb AP MoS at heel\u2010strike (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.033) when compared to HC. HA exhibited the least conservative non\u2010arthritic limb AP MoS at midstance (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.044), suggesting reduced AP stability. KA showed the smallest non\u2010arthritic limb ML MoS at heel\u2010strike (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.022), indicating greater lateral instability. Within all patient groups (HA, KA, AA), ML stability was more conservative in the arthritic limb compared to the non\u2010arthritic limb (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These findings suggest isolated lower extremity joint arthritis differentially impacts gait stability depending on the affected joint and limb, highlighting the need for targeted rehabilitation strategies to address stability deficits based on the joint impacted by arthritis.\n                  <\/jats:p>","DOI":"10.1002\/jor.70091","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:35:22Z","timestamp":1761219322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Margin of Stability During Walking Differs Between End\u2010Stage Hip, Knee, and Ankle Arthritis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-3197","authenticated-orcid":false,"given":"Renoa","family":"Choudhury","sequence":"first","affiliation":[{"name":"Kevin P. Granata Biomechanics Lab, Department of Biomedical Engineering and Mechanics Virginia Tech Blacksburg Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara L.","family":"Arena","sequence":"additional","affiliation":[{"name":"Kevin P. Granata Biomechanics Lab, Department of Biomedical Engineering and Mechanics Virginia Tech Blacksburg Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5181-9049","authenticated-orcid":false,"given":"Robin M.","family":"Queen","sequence":"additional","affiliation":[{"name":"Kevin P. Granata Biomechanics Lab, Department of Biomedical Engineering and Mechanics Virginia Tech Blacksburg Virginia USA"},{"name":"Department of Orthopaedic Surgery Virginia Tech Carilion School of Medicine Roanoke Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.15585\/mmwr.mm6609e1","article-title":"Vital Signs: Prevalence of Doctor\u2010Diagnosed Arthritis and Arthritis\u2010Attributable Activity Limitation\u2014United States","volume":"66","author":"Barbour K. E.","year":"2017","journal-title":"MMWR. 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