{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:15:42Z","timestamp":1788783342566,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aseptic loosening is a leading cause of total hip arthroplasty (THA) revision. While three dimensional (3D) multi\u2010spectral magnetic resonance imaging (MSI\u2010MRI) offers high sensitivity for detecting femoral stem loosening, it is less commonly acquired at routine follow\u2010up. This study investigates whether radiograph\u2010based radiomics can detect loosening confirmed by MSI\u2010MRI, improving routine evaluation of implant integration. In this cohort study, 3D MSI\u2010MRI acquisitions and standard AP pelvis radiographs were obtained from 38 symptomatic subjects with confirmed femoral component loosening and 40 asymptomatic subjects. Loosening was identified through qualitative evaluation of MSI\u2010MRI. A 2.5\u2009mm periprosthetic region was segmented from radiographs and divided into six Gruen zones. Radiographs were subdivided into overlapping patches (10\u2009\u00d7\u200910 to 150\u2009\u00d7\u2009150\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ) and a total of 96 radiomic features were extracted per patch. Features were standardized and reduced using principal component analysis. Logistic regression with L2 regularization was trained using five\u2010fold cross\u2010validation to classify symptomatic versus asymptomatic cases. Sixty\u2010four models were trained across zones and patch sizes. Gruen zones 3 (distal, lateral) and 7 (proximal, medial) achieved the highest performance (AUC\u2009=\u20090.76). The full periprosthetic model reached an AUC of 0.74 at 130\u2009\u00d7\u2009130\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    . Fewer principal components were required as patch size increased. Radiograph\u2010based radiomics can detect MSI\u2010MRI confirmed femoral component loosening in subjects with THA with high accuracy. As radiographs are routinely acquired in clinical practice, this method offers a scalable, low\u2010cost adjunct to standard post\u2010operative evaluation.\n                  <\/jats:p>","DOI":"10.1002\/jor.70120","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:25:29Z","timestamp":1765628729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiograph\u2010Based Radiomics Successfully Classify MRI\u2010Based Identification of Femoral Loosening in Patients With Total Hip Arthroplasty\u2014A Preliminary Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-4867","authenticated-orcid":false,"given":"Jack","family":"Consolini","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9742-1892","authenticated-orcid":false,"given":"Elizabeth G.","family":"Koretsky","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-9761","authenticated-orcid":false,"given":"Kevin M.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-6388","authenticated-orcid":false,"given":"Hollis G.","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-0183","authenticated-orcid":false,"given":"Matthew F.","family":"Koff","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001882"},{"key":"e_1_2_9_3_1","unstructured":"American Joint Replacement Registry. Annual Report 2024 [Internet]. 2024 [cited 2025 June 5].https:\/\/www.ajrr.net\/publications-data\/annual-reports."},{"issue":"10","key":"e_1_2_9_4_1","first-page":"7080","article-title":"Primary Total Hip Arthroplasty Failure: Aseptic Loosening Remains the Most Common Cause of Revision","volume":"14","author":"Feng X.","year":"2022","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1399-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200301000-00005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2021.01.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.12.024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/17453674.2023.26190"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-167"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4857-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199008000-00022"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"229","article-title":"Sequential Changes in Periprosthetic Bone Mineral Density Following Total Hip Arthroplasty: A 3\u2010year Follow\u2010up","volume":"21","author":"Ohta H.","year":"2003","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007760070047"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.03.044"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05881-y"},{"key":"e_1_2_9_17_1","unstructured":"American College of Radiology.American College of Radiology ACR Appropriateness Criteria for Imaging After Total Hip Arthroplasty [Internet].2023[cited 2024 August 21].https:\/\/acsearch.acr.org\/docs\/3094200\/Narrative\/."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000000772"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/TSMC.1973.4309314"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0339"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2019.06.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2007.08.009"},{"issue":"10","key":"e_1_2_9_24_1","first-page":"895","article-title":"Magnetic Resonance Imaging Findings in Symptomatic Versus Asymptomatic Subjects Following Metal\u2010on\u2010Metal Hip Resurfacing Arthroplasty","volume":"95","author":"Nawabi D. 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