{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:25:58Z","timestamp":1769682358015,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K17625"],"award-info":[{"award-number":["22K17625"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Post\u2010traumatic osteoarthritis after anterior cruciate ligament (ACL) injury is an important issue. Many patients with ACL injury undergo ligament reconstruction surgery, and the risk of osteoarthritis after ACL reconstruction may vary depending on the time between ACL injury and reconstruction surgery. We aimed to investigate the effects of timing of ACL reconstruction surgery on cartilage and meniscus degeneration. ACL\u2010transected rats were divided into groups based on the timing of reconstruction: immediate (1 day), early (14 days), and delayed (28 days) post\u2010ACL transection. Some ACL\u2010transected rats did not receive reconstruction surgery. Intact rats were used as controls. 56 days after ACL transection, cartilage and meniscus degeneration and synovitis were assessed histologically. ACL transection alone induced meniscus and cartilage degeneration and synovitis. ACL reconstruction, regardless of timing, enhanced synovitis. Immediate reconstruction reduced meniscus degeneration and had no negative effect on cartilage degeneration. In contrast, early and delayed reconstruction failed to reduce meniscus degeneration. Delayed reconstruction facilitated cartilage degeneration with an increased cyclooxygenase\u20102\u2010positive cell ratio compared with no reconstruction surgery. We speculate that worsening cartilage degeneration observed in the delayed reconstruction group was mediated by inflammatory reactions due to reconstruction surgery, which was enhanced by the excessive mechanical stress caused by meniscus degeneration. In the immediate reconstruction group, the negative effects of reconstruction surgery on the cartilage might be counteracted by the positive effect of meniscus protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statement of Clinical Significance<\/jats:title>\n                    <jats:p>Our results suggest that ACL reconstruction surgery should be performed as soon as possible to protect the meniscus, which affects cartilage degeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.70129","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:01:28Z","timestamp":1766980888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Timing of Anterior Cruciate Ligament Reconstruction Surgery After Injury Affects Development of Cartilage and Meniscus Degeneration in Rats"],"prefix":"10.1002","volume":"44","author":[{"given":"Akinori","family":"Kaneguchi","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Faculty of Rehabilitation Hiroshima International University Kurose\u2010Gakuendai 555\u201036 Higashi\u2010Hiroshima Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Kanehara","sequence":"additional","affiliation":[{"name":"Major in Medical Engineering and Technology, Graduate School of Medical Technology and Health Welfare Sciences Hiroshima International University Kurose\u2010Gakuendai 555\u201036 Higashi\u2010Hiroshima Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikazu","family":"Nishida","sequence":"additional","affiliation":[{"name":"Major in Medical Engineering and Technology, Graduate School of Medical Technology and Health Welfare Sciences Hiroshima International University Kurose\u2010Gakuendai 555\u201036 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