{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:25:50Z","timestamp":1769682350697,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007821","name":"AlloSource","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Premature physeal closure occurs following trauma, cancer, or infection. Current treatments have poor success rates. With recent pediatric donor tissue availability, physeal allograft transfer (PAT) can now be considered. The purpose of this study was to study the safety and feasibility of PAT in a large animal model. The aim of this study is to gather foundational data to inform future studies into the efficacy of PAT. Physeal defects were created in the distal femur of nine female domestic swine and treated with PAT from two male donor pigs, cementation, or bone autograft. Viability was assessed. After 3 months, physes were visualized using CT and MRI. Integration, tissue composition, donor DNA presence, and microscopic appearance were evaluated. Physeal allografts demonstrated 93% viability after procurement and preservation. All animals reached the 3\u2010months study endpoint without gross deformations. No physeal bars formed in any group. Cystic changes were seen in experimental and control femurs. All groups showed disorganized tissue architecture without growth plate recapitulation. High allografts viability and structural integrity after procurement support the potential of this treatment. Although no gross deformities were found, transferred physes demonstrate poor integration and incomplete repair. The lack of physeal bar formation in the control group limits the reliability of the animal model for studying physeal allograft transfer. Lastly, this study was designed as a feasibility study and lacks power to compare treatment effects statistically. The efficacy of PAT for preventing growth arrest remains undetermined.<\/jats:p>","DOI":"10.1002\/jor.70133","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T11:40:37Z","timestamp":1767526837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physeal Allograft Transfer for Physeal Bars: A Safety and Feasibility Study in a Domestic Swine Model"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1069-665X","authenticated-orcid":false,"given":"J. V.","family":"Korpershoek","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"},{"name":"Department of Orthopaedic Surgery University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"},{"name":"Department of Orthopedics Ditmanson Medical Foundation Chia\u2010yi Christian Hospital Chia\u2010yi Taiwan"},{"name":"Department of Orthopedic Surgery National Taiwan University Hospital Taipei Taiwan"},{"name":"School of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. V.","family":"Nagelli","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L.","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Floren","sequence":"additional","affiliation":[{"name":"Innovation Department AlloSource Centennial CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B. F.","family":"Saris","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"},{"name":"Department of Orthopaedic Surgery University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. A.","family":"Milbrandt","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"587","article-title":"Injuries Involving the Epiphyseal Plate","volume":"45","author":"Salter R. B.","year":"1963","journal-title":"Journal of Bone & Joint Surgery"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00347197"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.4.1780967"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198403000-00015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200501000-00007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199011000-00012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(94)90141-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035221126349"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520980087"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519888798"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-406"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200211000-00002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080412"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000003014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(87)80160-0"},{"key":"e_1_2_9_17_1","unstructured":"M.Fujita M.Mishima K.Iwabuchi et al. \u201cA Study on Type II Collagen\u2010Induced Arthritis in Allogeneic Bone Marrow Chimaeras \u201d (1989) 422427 p."},{"key":"e_1_2_9_18_1","first-page":"806","article-title":"Microvascular Transplantation of Physeal Allografts","volume":"77","author":"Boyer M.","year":"1995","journal-title":"Journal of Bone and Joint Surgery. 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I.Boyer E.Martens et al. \u201cAssessment of Epiphyseal Plate Allograft Viability and Function After Ex Vivo Storage in University of Wisconsin Solution.\u201d"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.70133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.70133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.70133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:56:25Z","timestamp":1769648185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.70133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jor.70133"],"URL":"https:\/\/doi.org\/10.1002\/jor.70133","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70133"}}