{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:36:14Z","timestamp":1769686574744,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Improving anterior cruciate ligament reconstruction (ACL\u2010R) healing remains a clinical challenge. Macrophages play a crucial role in musculoskeletal tissue injury repair. However, the mechanism by which macrophages modulate the healing after ACL\u2010R remains incompletely characterized. Macrophages with an interferon gene expression signature gradually accumulate at the bone\u2010to\u2010tendon interface during healing. This study investigated the effects of interferon signaling on ACL\u2010R healing using type I interferon receptor 1 (IFNAR1)\u2010deficient mice and an FDA\u2010approved JAK inhibitor baricitinib. Sixteen 12\u2010week\u2010old wildtype (WT) and\n                    <jats:italic>Ifnar1<\/jats:italic>\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice underwent ACL\u2010R surgery. Additionally, twenty\u2010two 12\u2010week\u2010old WT mice underwent ACL\u2010R and were treated with either baricitinib (10\u2009mg\/kg q24h p.o.) or vehicle control. The primary outcome measure was new bone formation in the bone tunnel, measured by \u03bcCT at 2 weeks post\u2010operatively. Secondary outcomes included knee histology, radiographs, and gait analysis. Results showed that new bone formation occurred in control conditions, and blocking interferon response via IFNAR1 deletion or baricitinib had minimal impact on this process. Histological analysis confirmed no significant differences in bone\u2010to\u2010tendon healing. Additionally, IFNAR1 deficiency or baricitinib treatment did not significantly affect post\u2010traumatic osteoarthritis (PTOA) development or gait. These findings suggest that interferon signaling does not play a major role in mediating the effects of macrophages on the bone\u2010to\u2010tendon healing processes after ACL\u2010R. Modulating interferon responses is unlikely to have a significant impact on healing outcomes in individuals undergoing ACL\u2010R surgery. This study provides insights into macrophage\u2010related healing mechanisms in ACL\u2010R and suggests that alternative pathways may be more relevant therapeutic targets.\n                  <\/jats:p>","DOI":"10.1002\/jor.70135","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:25:49Z","timestamp":1768973149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Type I Interferon Signaling and JAK Kinase Inhibition in a Mouse ACL Reconstruction Model"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-9886","authenticated-orcid":false,"given":"Wataru","family":"Morita","sequence":"first","affiliation":[{"name":"Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center Hospital for Special Surgery  New York NY USA"},{"name":"Department of Medicine Weill Cornell Medicine  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Orthopaedic Soft Tissue Research Program Hospital for Special Surgery  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Hyun","family":"Park\u2010Min","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center Hospital for Special Surgery  New York NY USA"},{"name":"Department of Medicine Weill Cornell Medicine  New York NY USA"},{"name":"BCMB allied program Weill Cornell Graduate School of Medical Sciences  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-9880","authenticated-orcid":false,"given":"Scott A.","family":"Rodeo","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine  New York NY USA"},{"name":"Orthopaedic Soft Tissue Research Program Hospital for Special Surgery  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel B.","family":"Ivashkiv","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center Hospital for Special Surgery  New York NY USA"},{"name":"Department of Medicine Weill Cornell Medicine  New York NY USA"},{"name":"Graduate Program in Immunology and Microbial Pathogenesis Weill Cornell Graduate School of Medical Sciences  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2016.08.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1805931"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2008.08.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-008-0560-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2013.05.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2634-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511402662"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2013.04.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00531"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10635"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019839650"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay4447"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.00133"},{"key":"e_1_2_8_15_1","article-title":"High\u2010Throughput, Multi\u2010Image Cryohistology of Mineralized Tissues","volume":"14","author":"Dyment N. 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