{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:12:54Z","timestamp":1779333174476,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071431"],"award-info":[{"award-number":["R01AR071431"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071335"],"award-info":[{"award-number":["R01AR071335"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Subchondral bone remodeling associated with symptomatic osteoarthritis (OA) is an error\u2010driven response affected by abnormal joint loading. Since different injury models of pre\u2010clinical OA may induce unique shifts in joint loading, comparing bone microstructural changes across different rat OA models may clarify the relationship between subchondral bone remodeling and the mechanisms of joint trauma. In this study, we compared bone microstructure measures across meniscal and anterior cruciate ligament models of late\u2010stage rat OA. OA was induced in male Lewis rats using via medial meniscus transection (MMT), anterior cruciate ligament transection (ACLT), and non\u2010invasive knee injury (NIKI, ACL rupture). At endpoint, microcomputed tomography was used to quantify trabecular and cortical bone microstructure. NIKI animals displayed unique changes in the subchondral bone plate and trabecular bone, where cortical (Ct.Th) and trabecular thickness (Tb.Th) decreased. In contrast, MMT and ACLT animals displayed varying levels of subchondral bone sclerosis with an increase in Ct.Th and Tb.Th compared to controls. Combined with the decreased bone volume (BV\/TV), trabecular number (Tb.N), and increased trabecular separation (Tb.Sp), bone changes in NIKI animals indicated varying amounts of bone loss. End\u2010stage bone changes differed across MMT, NIKI, and ACLT rat models of OA. Together, these data indicated that the mechanism of injury is an important consideration when evaluating OA pathophysiology at later time points of disease.<\/jats:p>","DOI":"10.1002\/jor.70176","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:00:11Z","timestamp":1774612811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathologic Changes in Subchondral Bone Microarchitecture Differ Between ACLT, NIKI, and MMT Models of Post\u2010Traumatic Osteoarthritis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-0304","authenticated-orcid":false,"given":"Markia T.","family":"Bowe","sequence":"first","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"},{"name":"Research Service, North Florida\/South Georgia Veterans Health System Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolulope O.","family":"Ajayi","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Oberdorfer","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"Sharma","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua F.","family":"Yarrow","sequence":"additional","affiliation":[{"name":"Research Service, North Florida\/South Georgia Veterans Health System Gainesville Florida USA"},{"name":"Geriatrics Research, Education, and Clinical Center VA Eastern Colorado Healthcare System Aurora Colorado USA"},{"name":"Division of Geriatric Medicine University of Colorado Anschutz School of Medicine Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle D.","family":"Allen","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"},{"name":"Department of Orthopedics and Sports Medicine University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063354"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-7-200104030-00007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22991"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.130"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198612000-00005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90235-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1054-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.05.023"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-011-0067-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"G.Li J.Yin J.Gao et al. \u201cSubchondral Bone in Osteoarthritis: Insight Into Risk Factors and Microstructural Changes \u201dArthritis Research & Therapy15 no. 6 (2013): 223 https:\/\/doi.org\/10.1186\/ar4405.","DOI":"10.1186\/ar4405"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:ABME.0000017541.82498.37"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465030310012401"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"E.Wellsandt E. 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