{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:12:58Z","timestamp":1779333178359,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The purpose of this exploratory pilot study was to compare the composition of humeral head (HH) and iliac crest (IC) bone marrow aspirates (BMA) and establish a framework for evaluating bone marrow aspirate concentrate (BMAC) in arthroscopic rotator cuff repair (RCR). Fifteen patients (mean age of 60, range: 41\u201374) with full\u2010thickness RC tears underwent arthroscopic RCR with BM aspiration (30\u2009mL) from both the HH and IC. Mononuclear cells (MNCs) before and after concentration, colony\u2010forming units (CFUs), and connective tissue progenitor cells (CTPs) after concentration were quantified. IC BMAC was injected at the site of RCR. A control cohort underwent RCR without BMAC. MRI analysis, dynamometer strength testing, range of motion, and ASES scores were assessed up to 12 months. Pre\u2010centrifugation MNC counts were similar between HH and IC (17.4 vs. 13.4 MNC\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.18). After centrifugation, IC demonstrated higher MNC concentration (64.6 vs. 29.7 MNC\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). CFUs did not differ significantly (1896 vs. 1047,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.17). Total CTPs were higher in IC (8338 vs. 3430,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035), although live CTPs were not significantly different (6013 vs. 2779,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.054). No significant associations were found between the number CTPs or CFUs and tendon healing on MRI. IC yields greater CTPs than HH, supporting its role as a preferred BMA source. However, BMAC augmentation was not associated with measurable differences in tendon healing or clinical outcomes at 12 months, which may be due to the limited sample size. Further studies are needed to refine cell isolation and optimize BMAC protocols for RCR augmentation.\n                  <\/jats:p>","DOI":"10.1002\/jor.70211","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:32:26Z","timestamp":1776954746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Humeral Head Versus Iliac Crest Bone Marrow Aspirate Concentrate in Patients Undergoing Arthroscopic Rotator Cuff Repair"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-919X","authenticated-orcid":false,"given":"Camila B.","family":"Carballo","sequence":"first","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sch\u00e4r","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-5755","authenticated-orcid":false,"given":"Claire D.","family":"Eliasberg","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin R.","family":"Leatherman","sequence":"additional","affiliation":[{"name":"Kenyon College Gambier Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Cavanaugh","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ying","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei","family":"Rudchenko","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollis","family":"Potter","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Warren","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Rodeo","sequence":"additional","affiliation":[{"name":"The Hospital for Special Surgery (HSS) New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2006.06.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00739"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514529644"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04634-6"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"1229","article-title":"Arthroscopic Repair of Full\u2010Thickness Tears of the Supraspinatus: Does the Tendon Really Heal?","volume":"87","author":"Boileau P.","year":"2005","journal-title":"Journal of Bone and Joint Surgery\u2010American"},{"issue":"16","key":"e_1_2_8_7_1","article-title":"Enthesis Repair: Challenges and Opportunities for Effective Tendon\u2010to\u2010Bone Healing","volume":"100","author":"Derwin K. 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R Foundation for Statistical Computing 2\u201d (Team RDC 2020)."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v069.i01"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.08.021"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509360924"},{"issue":"6","key":"e_1_2_8_20_1","first-page":"517","article-title":"Variability in the Preparation, Reporting, and Use of Bone Marrow Aspirate Concentrate in Musculoskeletal Disorders: A Systematic Review of the Clinical Orthopaedic Literature","volume":"100","author":"Piuzzi N. S.","year":"2018","journal-title":"Journal of Bone and Joint Surgery\u2014American"},{"issue":"10","key":"e_1_2_8_21_1","first-page":"809","article-title":"Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet\u2010Rich Plasma and Mesenchymal Stem Cells","volume":"99","author":"Murray I. R.","year":"2017","journal-title":"Journal of Bone and Joint Surgery\u2014American"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2018.10.1.99"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1607-9"},{"issue":"7","key":"e_1_2_8_24_1","first-page":"326","article-title":"Revision Rotator Cuff Reconstruction for Large Tears With Retraction: A Novel Technique Using Autogenous Tendon and Autologous Marrow","volume":"44","author":"Skoff H. 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