{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:06:34Z","timestamp":1787673994947,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU\u2010TC114A02"],"award-info":[{"award-number":["KMU\u2010TC114A02"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Post\u2010traumatic knee osteoarthritis develops following acute joint injuries and can progress rapidly, causing significant morbidity. Intra\u2010articular hyaluronic acid injections are a common treatment, but efficacy varies between formulations. We hypothesized that cross\u2010linked hyaluronic acid would provide superior chondroprotective and anti\u2010inflammatory effects compared to linear hyaluronic acid in a standardized post\u2010traumatic osteoarthritis model. Post\u2010traumatic osteoarthritis was induced via anterior cruciate ligament transection in 84 male Sprague\u2010Dawley rats assigned to four groups: Sham (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912), untreated osteoarthritis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924), linear hyaluronic acid\u2014Jetknee (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924), or cross\u2010linked hyaluronic acid\u2014HYAJOINT Plus (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924). At each of four time points (Day 7, Week 4, Week 8, and Week 12 post\u2010surgery), three Sham and six rats per treatment group were sacrificed. Functional recovery was assessed by weight\u2010bearing distribution. Cartilage integrity was evaluated histologically using hematoxylin and eosin and Safranin O staining, scored with the Osteoarthritis Research Society International histopathological grading system. Immunohistochemical expression of type II collagen, type X collagen, matrix metalloproteinase\u201013, and tumor necrosis factor\u2010alpha was analyzed. Both hyaluronic acid formulations significantly improved weight\u2010bearing compared to untreated controls. Cross\u2010linked hyaluronic acid demonstrated more sustained functional recovery and superior cartilage preservation with lower histological scores. Immunohistochemistry revealed reduced catabolic and inflammatory marker expression with higher type II collagen in the cross\u2010linked hyaluronic acid group. High molecular weight cross\u2010linked hyaluronic acid conferred stronger and longer\u2010lasting chondroprotective effects than linear hyaluronic acid, suggesting that structural optimization of hyaluronic acid formulations may confer more sustained chondroprotective effects in this preclinical model of post\u2010traumatic osteoarthritis.\n                  <\/jats:p>","DOI":"10.1002\/jor.70213","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:48:11Z","timestamp":1777283291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cross\u2010Linked Versus Linear Hyaluronic Acid for Cartilage Repair in Rat Post\u2010Traumatic Osteoarthritis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-8079","authenticated-orcid":false,"given":"Tien\u2010Ching","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Orthopedics, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Ming","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wun","family":"Lin","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1604-0914","authenticated-orcid":false,"given":"Yi\u2010Shan","family":"Lin","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 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