{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:08:14Z","timestamp":1790690894562,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute compartment syndrome (ACS) is common in trauma, challenging early diagnosis and treatment. An accurate ACS model is vital for its management. Most prior animal models have induced intrafascial hypertension by exogenous interventions, focusing on the study of secondary injury post\u2010ACS formation. A novel rat model with spontaneous ACS formation after trauma was constructed, emphasizing early onset and development. The 300\u2010mmHg pressure simulated by a blood pressure cuff was applied to rat hindlimbs for 3\u2009h. A balloon catheter connected to a manometer was developed, and intracompartmental pressure (ICP) and blood perfusion were measured continuously for 2\u2009h. H&amp;E staining and serum index were detected at 0, 1\u2010, 2\u2010, 3\u2010, and 8\u2010h postinjury. The results showed injured hindlimbs swelled, with ICP rising continuously, reaching 30\u2009mmHg in 35\u2009min, peaking at 60\u201380\u2009min before entering a plateau period, effectively reproducing ACS pressure evolution. The blood perfusion showed a three\u2010step change, negatively correlating with ICP\u2009&gt;\u200930\u2009mmHg. Muscle tissues presented typical time\u2010dependent pathological changes, with progressive myofibrillar rupture, inflammatory cell infiltration, and increases in serum IL\u20101\u03b2, TNF\u2010\u03b1, CK, and BUN over time. This study successfully established a new preclinical ACS\u2010like rat model. Compared with previous studies, the ICP in the hindlimbs in this study was spontaneously elevated after crush, leading to secondary injury. Furthermore, a new manometric catheter device was developed to enable continuous monitoring of ICP without repeated fluid injections. The constructed animal model is closer to the clinic, and it lays a solid foundation for ACS pathogenesis.<\/jats:p>","DOI":"10.1002\/jor.70262","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T13:23:41Z","timestamp":1787491421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Preclinical Rat Model of Acute Compartment Syndrome"],"prefix":"10.1002","volume":"44","author":[{"given":"Sishu","family":"Guan","sequence":"first","affiliation":[{"name":"War Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"},{"name":"Emergency Department The General Hospital of Western Theater Command Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute for Traffic Medicine, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"War Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.70036"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00277-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.13270"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2020.02.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-215078"},{"issue":"10","key":"e_1_2_13_7_1","article-title":"Treating Fasciotomy Wounds With Negative Pressure Wound Therapy With Instillation and Dwell Time (NPWTi\u2010d)","volume":"8","author":"Lee P.","year":"2016","journal-title":"Cureus"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.5606\/tftrd.2023.13041"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01405-0"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B8.36325"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2021-102735"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016260"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usae211"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05131-x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2010.0699"},{"issue":"4","key":"e_1_2_13_16_1","first-page":"631","article-title":"Quantitation of Skeletal\u2010Muscle Necrosis in a Model Compartment Syndrome","volume":"63","author":"Hargens A. 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