{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:46:20Z","timestamp":1792154780422,"version":"4.4.0"},"reference-count":80,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32AR073157"],"award-info":[{"award-number":["T32AR073157"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR086404"],"award-info":[{"award-number":["R21AR086404"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008616","name":"Rush University","doi-asserted-by":"publisher","award":["Cohn Fellowship"],"award-info":[{"award-number":["Cohn Fellowship"]}],"id":[{"id":"10.13039\/100008616","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008616","name":"Rush University","doi-asserted-by":"publisher","award":["Michael and Jacqueline Newman Orthopaedic Research Fund"],"award-info":[{"award-number":["Michael and Jacqueline Newman Orthopaedic Research Fund"]}],"id":[{"id":"10.13039\/100008616","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008616","name":"Rush University","doi-asserted-by":"publisher","award":["The Lemann Fund"],"award-info":[{"award-number":["The Lemann Fund"]}],"id":[{"id":"10.13039\/100008616","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Evidence indicates that alpha angle (AA) is inadequate for describing cam morphology, contributing to poor patient selection and clinical outcomes for cam\u2010type femoroacetabular impingement syndrome (FAI). While techniques such as statistical shape modeling (SSM) have advanced knowledge of 3D femoral morphology, many studies utilize computed tomography, which incurs ionizing radiation, or small sample sizes, limiting clinical implementation and generalization. Here, we conducted SSM using MRI\u2010derived 3D femur models from a large cohort of FAI patients to explore: (1) What proximal femur features drive shape variability? (2) What variability exists within the area of the cam deformity? (3) Are shape modes correlated to AA, age, sex, and BMI? 103 FAI patients were enrolled (\u00b5\u2009\u00b1\u2009\u03c3): Age (29.9\u2009\u00b1\u200912.1 Years), BMI (24.6\u2009\u00b1\u20094.8), AA (60.3\u00b0\u2009\u00b1\u20099.8), Female\/Male (75\/28). Shape modes were determined through principal component analysis. Relationships between shape modes and AA, age, and BMI were evaluated through linear regression. Sex differences were analyzed using linear discriminant analysis. Thirteen modes explained 91.0% of femoral shape variance, with the first six modes explaining 82.2%, four of which were associated with the cam deformity region. No relationship was found between any mode versus AA, BMI, or age. Sex\u2010based shape differences were primarily captured by the first mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>The proximal femur in cam\u2010type FAI patients demonstrated substantial regional shape variability, with cam\u2010related morphology distributed across multiple independent modes rather than a single uniform deformity pattern. Sex was a major driver of proximal femoral shape variation. These findings may inform morphology\u2010based classification, outcome analysis, and patient\u2010specific surgical planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.70285","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:53:18Z","timestamp":1791183198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Not All Cams Are Equal: MRI\u2010Based Statistical Shape Modeling Reveals High Variability in Cam Shape in a Large FAI Cohort"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2544-5906","authenticated-orcid":false,"given":"Catherine","family":"Yuh","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Malloy","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"},{"name":"Department of Physical Medicine and Rehabilitation Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sage","family":"Zonner","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Gerhold","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Chahla","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane J.","family":"Nho","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-9336","authenticated-orcid":false,"given":"Steven P.","family":"Mell","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096743"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000096804.78689.c2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.114"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-1945-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201643"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0060-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520970914"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.01.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2022.100275"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24509"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.11.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25332"},{"issue":"3","key":"e_1_2_9_14_1","article-title":"Hip and Pelvis Movement Patterns in Patients With Femoroacetabular Impingement Syndrome Differ From Controls and Change After Hip Arthroscopy During a Step\u2010Down Pivot\u2010Turn Task","volume":"11","author":"Alter T. 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