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Thirty\u2010five 24\u2010week\u2010old male N:NIH rats selectively bred for high aerobic capacity (high\u2010capacity\u2010runner [HCR];\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917) and low aerobic capacity (low\u2010capacity\u2010runner [LCR];\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918) were fed either a high\u2010fat\/high\u2010sucrose (HFHS) diet or a chow diet for 12 weeks. Alterations in articular cartilage, subchondral bone microarchitecture, IFP hypertrophy, and synovial membrane cytokine levels were quantified. Body composition, serum cytokines, and glucose tolerance were assessed at Week 12. Compared to HCR rats, LCR rats had higher modified Mankin scores, bone volume, total volume, bone mineral density, bone volumetric fraction, and trabecular thickness, and lower specific bone surface, bone surface density, and connectivity density. LCR rats also had higher RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) and lower EGF (epidermal growth factor) levels in synovium analytes. Furthermore, in response to the HFHS diet, there were no differences in adipocyte hypertrophy within the IFP for either the HCR or LCR rats. LCR rats demonstrated hyperglycemia, elevated pro\u2010inflammatory marker levels, and decreased anti\u2010inflammatory marker levels compared to HCR rats. It was concluded that intrinsic high aerobic capacity maintains superior knee joint integrity both with and without an obesogenic dietary challenge, likely due to superior metabolic resistance. Whether intrinsic high aerobic capacity might protect joint degeneration in obesity and metabolic syndrome in other species including humans, warrants investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.70299","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:07:48Z","timestamp":1792433268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Variation in Intrinsic Aerobic Capacity Reveals Distinct Differences in the Maintenance of Rat Knee Joint Integrity"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6318-4824","authenticated-orcid":false,"given":"Darsh","family":"Tripathi","sequence":"first","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-2264","authenticated-orcid":false,"given":"Mauricio","family":"Delgado\u2010Bravo","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"},{"name":"Carrera de Kinesiolog\u00eda, Departamento de Ciencias de la Salud Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Seerattan","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-881X","authenticated-orcid":false,"given":"Venus","family":"Joumaa","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-294X","authenticated-orcid":false,"given":"David A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"},{"name":"Department of Surgery University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5088-7947","authenticated-orcid":false,"given":"Raylene A.","family":"Reimer","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"},{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2019-5939","authenticated-orcid":false,"given":"Lauren Gerard","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology College of Medicine and Life Sciences, The University of Toledo Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-0033","authenticated-orcid":false,"given":"Walter","family":"Herzog","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary Calgary Alberta Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39842"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114939"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-1-18"},{"issue":"2","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00001648-199903000-00013","article-title":"Body Weight, Body Mass Index, and Incident Symptomatic Osteoarthritis of the Hand, Hip, and Knee","volume":"10","author":"Oliveria S. 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