{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:19:09Z","timestamp":1760919549748,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HL007734","F32DK104525\u201001"],"award-info":[{"award-number":["5T32HL007734","F32DK104525\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to characterize fatty acid profiles (FAPs) in parenteral nutrition (PN)\u2010dependent infants with intestinal failure\u2013associated liver disease (IFALD) receiving soybean oil\u2013based lipid emulsion (SO) doses of \u223c3 and \u223c1 g\/kg\/d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively collected data were retrospectively reviewed. Serum FAPs of patients &lt;1 year old who experienced development of IFALD while receiving standard PN with SO were examined before transitioning to a fish oil\u2013based lipid emulsion for IFALD treatment. Time on SO, dose, gestational age, and weight\u2010 and length\u2010for\u2010age <jats:italic>z<\/jats:italic> scores were also reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 49 patients analyzed, there were no differences in demographics or anthropometrics between patients who received standard SO (SO\u2010S) (n = 14, range of dosage 2.06\u20133.31 g\/kg\/d) and reduced SO (SO\u2010R) (n = 35, range of dosage 0.90\u20131.34 g\/kg\/d). Patients received SO for a median of 53 days (interquartile range 39, 73) before FAP measurement. Patients who received SO\u2010R had significantly higher Mead acid and lower \u03b1\u2010linolenic, eicosapentaenoic, linoleic, stearic, total \u03c9\u20103, and total \u03c9\u20106 fatty acid levels than patients who received SO\u2010S (<jats:italic>P<\/jats:italic> &lt; .01). Triene:tetraene ratios were higher in patients who received SO\u2010R (<jats:italic>P<\/jats:italic> = .0009), and no patients experienced biochemical essential fatty acid deficiency (EFAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PN\u2010dependent infants with IFALD receiving SO\u2010R have different FAPs than patients receiving SO\u2010S. No patients in either group had biochemical EFAD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1026","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T11:23:39Z","timestamp":1695900219000},"page":"71-77","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of Fatty Acid Profiles in Infants With Intestinal Failure\u2013Associated Liver Disease"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-9546","authenticated-orcid":false,"given":"Meredith A.","family":"Baker","sequence":"first","affiliation":[{"name":"Vascular Biology Program and Department of Surgery Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research Boston Children's Hospital  Boston Massachusetts 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