{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:27:36Z","timestamp":1791404856701,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intestinal barrier plays an essential role in maintaining gastrointestinal health. This study aimed to explore the effects of a soluble mediator preparation derived from <jats:italic>Lactobacillus rhamnosus<\/jats:italic> Gorbach\u2010Goldin (LGG) on intestinal barrier function in a rat model of short bowel syndrome (SBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six\u2010week\u2010old male Sprague\u2010Dawley rats underwent 80% small\u2010bowel resection (SBR) and then were supplemented with water (SBS), 5 \u00d7 10<jats:sup>8<\/jats:sup> colony\u2010forming unit viable LGG (SBS+LGG), or the LGG soluble mediators (SBS+LSM) in an equivalent dose to LGG by intragastric gavage daily from day 2 throughout day 14 after operation. Rats that underwent bowel transection and reanastomosis were used as the sham group. Body weight, ileum histology, intestinal permeability and bacterial translocation, inflammatory cytokines, and tight junction protein expressions of ileum were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Animals undergoing SBR showed higher intestinal permeability and decreased expression of tight junction proteins in the ileum than sham group. Both SBS+LGG and SBS+LSM groups had reduced bacterial translocation and intestinal permeability as compared with the SBS group, with lower levels of serum endotoxin and tumor necrotizing factor alpha in ileum tissues. Moreover, the SBS+LSM group showed better body weight gain, lower endotoxin and FD\u201040 levels, and higher expressions of claudin\u20101 and claudin\u20104 in ileum than the SBS+LGG group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enteral supplementation of LSMs or viable LGG can ameliorate intestinal barrier disruption in a rat model of SBS. The LSM preparation not only mimicked biological effects of viable LGG but also was revealed to be more effective in reducing inflammation and supporting intestinal barrier function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1044","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T08:38:46Z","timestamp":1515573526000},"page":"1026-1034","source":"Crossref","is-referenced-by-count":11,"title":["Soluble Mediators From <i>Lactobacillus rhamnosus<\/i> Gorbach\u2010Goldin Support Intestinal Barrier Function in Rats After Massive Small\u2010Bowel Resection"],"prefix":"10.1002","volume":"42","author":[{"given":"Jiang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Institute for Pediatric Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingya","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Institute for Pediatric Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Mead Johnson Pediatric Nutrition Institute  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Gross","sequence":"additional","affiliation":[{"name":"Mead Johnson Pediatric Nutrition Institute  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim T.","family":"Lambers","sequence":"additional","affiliation":[{"name":"Mead Johnson Pediatric Nutrition Institute  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A. 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