{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:02:38Z","timestamp":1791514958843,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Enteral nutrition (EN) is more beneficial than parenteral nutrition (PN) in reducing organ failure, infectious complications, and mortality of acute pancreatitis (AP), but its timing is controversial. We attempted to evaluate the safety and clinical outcomes of early EN within 24 hours of admission in patients with AP, especially in predicted severe or severe acute pancreatitis (SAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, EMBASE Databases, Web of Science, and the Cochrane Library for relevant articles before June 2016 using RevMan 5.2 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies containing 727 patients with AP were analyzed in the meta\u2010analysis. Comparing early EN to late EN or total parental nutrition in AP, the odds ratios (OR) were 0.56 (95% CI 0.23 \u20131.34) for the risk of mortality, 0.40 (95% CI 0.20\u20130.79) for multiple organ failure, 0.57 (95% CI 0.23\u20131.42) for infectious complications, 0.45 (95% CI 0.17\u20131.21) for adverse events, and 0.83 (95% CI 0.59\u20131.18) for pancreatic\u2010related infections. Furthermore, subgroup analysis for early EN in predicted severe or SAP showed a significant reduction in multiple organ failure (OR 0.30; 95% CI 0.09\u20130.96) and pancreatic\u2010related infections (OR 0.51, 95% CI 0.29\u20130.88). Early EN provided no benefits for mild to moderate AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early EN within 24 hours of admission is safe and provides benefits for predicted severe or SAP, but not for mild to moderate pancreatitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1139","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T13:34:29Z","timestamp":1517232869000},"page":"1139-1147","source":"Crossref","is-referenced-by-count":37,"title":["Meta\u2010Analysis of Early Enteral Nutrition Provided Within 24 Hours of Admission on Clinical Outcomes in Acute Pancreatitis"],"prefix":"10.1002","volume":"42","author":[{"given":"Desheng","family":"Qi","sequence":"first","affiliation":[{"name":"Emergency Department Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milin","family":"Peng","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200011000-00001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01813.x"},{"issue":"1","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0002-9610(05)80403-9","article-title":"Pathogenesis of pancreatic sepsis","volume":"165","author":"Medich DS","year":"1993","journal-title":"Am J Surg"},{"issue":"2","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00000658-199408000-00011","article-title":"Time course of bacterial infection of the pancreas and its relation to disease severity in a rodent model of acute necrotizing pancreatitis","volume":"220","author":"Foitzik T","year":"1994","journal-title":"Ann Surg"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0574"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"4","article-title":"Pancreatitis and nutrition. 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