{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:50:03Z","timestamp":1793407803337,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T00:00:00Z","timestamp":1517097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Department of Defense Medical Research and Materiel Command"},{"name":"Entrinsic Health Solutions, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of different commercial beverage compositions for meeting oral rehydration therapy (ORT) goals in the treatment of acute dehydration in healthy humans has not been systematically tested. The objective of the study was to compare fluid retention, plasma volume (PV), and interstitial fluid (ISF) volume restoration when using 1 popular glucose\u2010based and 1 novel amino acid\u2013based (AA) commercial ORT beverage following experimental hypertonic or isotonic dehydration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six healthy adults (21 males, 5 females) underwent either a controlled bout of hypertonic (n = 13) or isotonic (n = 13) dehydration (3%\u20134% body mass) via eccrine or renal body water and electrolyte losses induced using exercise\u2010heat stress (EHS) or Lasix administration (LAS), respectively. Rehydration was achieved over 90 minutes by matching fluid intake to water losses (1:1) using a sports drink (SP) or AA commercial ORT beverage. Fluid retention (water and electrolytes), PV, and ISF volume changes were tracked for 180 minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AA produced significantly (<jats:italic>P<\/jats:italic> &lt;0.05) greater fluid retention (75% vs 57%), ISF volume restoration, and tended (<jats:italic>P<\/jats:italic> = 0.06) to produce greater PV restoration in trial EHS. In trial LAS, neither beverage exceeded 65% retention, but AA replaced electrolytes and preserved ISF volume better than SP (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study demonstrate superior rehydration when using AA compared with SP for both hypertonic and isotonic dehydration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1142","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T15:04:31Z","timestamp":1517238271000},"page":"1185-1193","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of Glucose or Amino Acid\u2013Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration"],"prefix":"10.1002","volume":"42","author":[{"given":"Samuel N.","family":"Cheuvront","sequence":"first","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine  Natick MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Kenefick","sequence":"additional","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine  Natick MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Charkoudian","sequence":"additional","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine  Natick MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine  Natick MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Luippold","sequence":"additional","affiliation":[{"name":"U.S. Army Research Institute of Environmental Medicine  Natick MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karleigh 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