{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:05:54Z","timestamp":1789517154684,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review all cases of parenteral support (PS)\u2013dependent patients with short bowel syndrome (SBS) treated with teduglutide (Gattex, Shire) and to evaluate its efficacy and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective descriptive cohort of SBS patients treated with teduglutide. Demographics, bowel length, primary diagnosis, PS volume\/duration, teduglutide dose, and side effects were collected prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six SBS patients (4 females, 2 males) received teduglutide. Mean age was 46.3 years (range 26\u201371). SBS etiology was vascular (n = 3), multiple resections (n = 2), and strangulation (n = 1). Length of residual small bowel was between 30\u2013120 cm. The bowel anatomy was colon present (n = 3) and stoma n = 3 (ileostomy, 2; colostomy, 1). PS duration was 1.5\u201314 years. Weekly PS volume was mean 7.7 liters\/week (1\u201314). Number of PS days per week ranged 1\u20137 days. Mean duration of teduglutide therapy was 31 months (24\u201336). All patients achieved \u226520% reduction in PS weekly volume within 6 months. PS was weaned in all patients. Adverse effects included abdominal bloat\/discomfort (n = 3), stoma enlargement (n = 3), bowel obstruction (n = 1), and congestive heart failure (n = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All PS\u2010dependent SBS patients treated with teduglutide were weaned off PS. Patients with colon in continuity and lower PS weekly volume requirements were weaned off PS sooner than those with end\u2010stomas and higher PS volume requirements. Teduglutide was well tolerated. Additional clinical studies of teduglutide in SBS patients with marginal PS requirements are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1149","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T02:43:26Z","timestamp":1522464206000},"page":"821-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010Term Therapy With Teduglutide in Parenteral Support\u2013Dependent Patients With Short Bowel Syndrome: A Case Series"],"prefix":"10.1002","volume":"42","author":[{"given":"Andrew","family":"Ukleja","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau","family":"To","sequence":"additional","affiliation":[{"name":"St. John's Episcopal Hospital Far Rockaway  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Gastro Health  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Lara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00710.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.08.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.784700"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31068"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114525210"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9077-5"},{"key":"e_1_2_6_8_1","article-title":"Short bowel patients treated for two years with glucagon\u2010like Peptide 2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function","author":"Jeppesen PB","year":"2009","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S13906"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000120"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111414431"},{"key":"e_1_2_6_14_1","first-page":"138","article-title":"Final results of STEPS\u20102, a 2\u2010year multicenter open\u2010label clinical trial: safety and efficacy of long\u2010term teduglutide 0.05 mg\/kg\/daytreatment for intestinal failure associated with short bowel syndrome","volume":"38","author":"Fujioka K","year":"2014","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000046"},{"issue":"1","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/S0261-5614(14)50465-7","article-title":"Teduglutide for patients with short bowel syndrome. 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