{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:32:37Z","timestamp":1784140357196,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Pediatric\u2010onset intestinal failure (IF) remains a severe illness with life\u2010threatening consequences. In this study, we analyzed a single center's outcomes of IF over 3 decades. <jats:italic>Methods<\/jats:italic>: All children with IF who required parenteral nutrition (PN) &gt;2 months or small\u2010intestinal resection \u226550% managed since 1984 were included for retrospective outcome analyses. <jats:italic>Results<\/jats:italic>: In total, 100 patients with median PN duration of 1.2 (interquartile range, 0.4\u20133.5) years were identified. Causes of IF were short bowel syndrome (SBS; n = 78), primary intestinal motility disorders (n = 14), and congenital intestinopathies (n = 8). Patients with SBS had median 40 (25\u201360) cm of small bowel remaining. Overall, Kaplan\u2010Meier 5\u2010 and 10\u2010year weaning\u2010off estimates were 67% (95% CI, 57\u201377) and 73% (95% CI, 63\u201384), respectively. Weaning off PN was predicted by remaining bowel anatomy, multidisciplinary treatment era, and absence of immune deficiency. Catheter\u2010related bloodstream infections decreased from 1.4 to 0.6\/1000 PN days (<jats:italic>P<\/jats:italic> = .0003) with systematic use of taurolidine locks. None had progressive liver disease. Thirty\u2010one percent of patients with SBS underwent autologous intestinal reconstructive surgery. Five patients received and 2 were listed for isolated intestinal transplantation. Eight patients died, and overall 15\u2010year survival rate estimate was 91% (95% CI, 85\u201398). <jats:italic>Conclusions<\/jats:italic>: Despite reassuring rates of survival and weaning off PN, long\u2010term PN failed in 14% of patients solely because of catheter complications in the recent era. Achievement of enteral autonomy in those with the shortest remaining small bowel and functional cause of IF remains challenging.<\/jats:p>","DOI":"10.1002\/jpen.1164","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T10:02:39Z","timestamp":1524823359000},"page":"1304-1313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Pediatric Intestinal Failure: The Key Outcomes for the First 100 Patients Treated in a National Tertiary Referral Center During 1984\u20132017"],"prefix":"10.1002","volume":"42","author":[{"given":"Laura","family":"Merras\u2010Salmio","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Helsinki University Children's Hospital  Helsinki Finland"},{"name":"Pediatric Liver and Gut Research Group University of Helsinki  Helsinki 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