{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:51:31Z","timestamp":1781801491159,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The milk fat globule membrane (MFGM) contains various bioactive components which have been shown to maintain gut barrier integrity. This study aimed to evaluate the protective effects of MFGM on intestinal barrier function and its possible mechanisms in a rat model of short bowel syndrome (SBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Five\u2010week\u2010old male Sprague\u2010Dawley rats were divided into 3 groups (n = 8 per group), consisting of Sham group and rats submitted to massive small\u2010bowel resection then supplemented with either water (SBS) or 1.5g\/kg\/d MFGM (SBS+MFGM) by daily gavage. Rats were sacrificed on day 15 postoperation. Intestinal adaptation, gut permeability, bacterial translocation (BT), expression of tight junction proteins, mucin 1 (MUC1), and nucleotide\u2010binding oligomerization domain leucine\u2010rich repeat and pyrin domain\u2013containing protein 3 (NLRP3) pathway in the ileum were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both SBS+MFGM and SBS groups exhibited lower body weight and higher ileum villus height than Sham group, but no difference was detected between each other. SBS group had significantly higher intestinal permeability and BT rate than other groups (<jats:italic>P<\/jats:italic> &lt; .05). Compared with SBS rats, SBS+MFGM group showed higher expression of tight junction proteins and MUC1, lower expression of NLRP3 and caspase\u20101 in the ileum, as well as lower interleukin (IL)\u20101\u03b2 but higher IL\u201018 levels in ileum tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Supplementation of MFGM helps to modulate NLRP3 inflammasome activation and enhances gut barrier integrity in rats after massive small\u2010bowel resection, which provides experimental support for potential applications of MGFM in intestinal barrier dysfunction, although further studies are needed<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1435","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T07:40:40Z","timestamp":1535096440000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel"],"prefix":"10.1002","volume":"43","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai 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Pediatric Nutrition Institute  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition  Shanghai China"},{"name":"Department of Pediatric Surgery Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai 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