{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:59:04Z","timestamp":1792598344197,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n We assessed the impact of a standardized nutrition initiative for very low\u2010birth\u2010weight (VLBW) infants on their nutrition and clinical outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective analysis of VLBW infants born before and after the initiation of a nutrition protocol. This protocol included trophic feeds, feeding advancement, fortification guidelines, parameters on the concentration of parenteral nutrition (PN), and the discontinuation of PN and central lines. Gastric residual monitoring was discontinued. Statistical analyses were performed with Fisher's exact and Student's\n t<\/jats:italic>\n \u2010tests. Primary outcome measures were days receiving PN, days made nil per os (NPO) after feeding initiation, necrotizing enterocolitis, and growth parameters. Secondary outcome measures were central\u2010line days, sepsis, blood transfusions, cholestasis, osteopenia, chronic lung disease, and retinopathy of prematurity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 136 VLBW infants were analyzed, including 77 in the preprotocol group and 59 in the postprotocol group. Infants postprotocol were found to have reduced PN days (26.1 versus [vs] 18.4,\n P<\/jats:italic>\n < .01), fewer days made NPO after feeding initiation (7.2 vs 4.0,\n P<\/jats:italic>\n = .02), NEC (7.8% vs 0%,\n P<\/jats:italic>\n = 0.038), central\u2010line days (26.5 vs 18.6,\n P<\/jats:italic>\n < .01), cholestasis (16% vs 3%,\n P<\/jats:italic>\n \u00a0=\u00a0.02), and blood transfusions (5.3 vs 3.1,\n P<\/jats:italic>\n = .028). Growth, defined by change in\n z<\/jats:italic>\n \u2010score from birth to discharge, improved for weight (\u22121.3 vs \u22120.8,\n P<\/jats:italic>\n < .01), length (\u22121.5 vs \u22121.0,\n P<\/jats:italic>\n = .033), and head (\u22121.1 vs \u22120.6,\n P<\/jats:italic>\n = .024).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Initiation of a standardized nutrition initiative for VLBW infants significantly improved growth, reduced PN use, and improved patient outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jpen.1453","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T21:27:57Z","timestamp":1541798877000},"page":"540-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Standardized Nutrition Protocol for Very Low\u2010Birth\u2010Weight Infants Resulted in Less Use of Parenteral Nutrition and Associated Complications, Better Growth, and Lower Rates of Necrotizing Enterocolitis"],"prefix":"10.1002","volume":"43","author":[{"given":"Priscilla A.","family":"Barr","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition Services NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep V.","family":"Mally","sequence":"additional","affiliation":[{"name":"Division of Neonatology Hassenfeld Children's Hospital at NYU Langone New York University School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-0720","authenticated-orcid":false,"given":"Martha C.","family":"Caprio","sequence":"additional","affiliation":[{"name":"Division of Neonatology Hassenfeld Children's Hospital at NYU Langone New York University School of Medicine New York New York 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