{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:41:54Z","timestamp":1787496114035,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population\u2010based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants.\n                    <jats:italic>Methods<\/jats:italic>\n                    : We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants \u226412 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow\u2010up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA.\n                    <jats:italic>Results<\/jats:italic>\n                    : A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) &gt;3.5 IU\/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12\u2010month telephone follow\u2010up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12\u2010month follow\u2010up, the majority of CMPA infants had become tolerant to CMP.\n                  <\/jats:p>","DOI":"10.1002\/jpen.1472","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T10:40:37Z","timestamp":1542624037000},"page":"803-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population\u2010Based Survey"],"prefix":"10.1002","volume":"43","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Guangzhou Women and Children's Medical Center of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Healthcare Guangzhou Women and Children's Medical Center of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Healthcare Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jiangmen Maternity and Child Health Care Hospital  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boai Hospital of Zhongshan  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenzhen Maternity &amp; Child Healthcare Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabo","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Healthcare Dongguan Maternal and Child Health Care Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Guangzhou Women and Children's Medical Center of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Healthcare Guangzhou Women and Children's Medical Center of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijin","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Healthcare Panyu Campus Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Healthcare Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Healthcare Jiangmen Maternity and Child Health Care Hospital  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boai Hospital of Zhongshan  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Healthcare Shenzhen Maternity &amp; Child Healthcare Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Healthcare Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dongguan Maternal and Child Health Care Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Guangzhou Women and Children's Medical Center of Guangzhou Medical University  Guangzhou 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