{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:48:17Z","timestamp":1788446897547,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012400","name":"Sigma Theta Tau International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malnutrition increases the risk of mortality and morbidity in the pediatric intensive care unit (PICU). Barriers to adequate delivery of enteral nutrition (EN) include hemodynamic instability, feeding interruptions and intolerance, and lack of standardized feeding protocols. The most recent guidelines on nutrition support for the critically ill child describe a paucity of evidence around the best method to deliver EN. There is an untested clinical assumption that bolus gastric feeding (B\u2010GF) in intubated patients is associated with aspiration events, lung injury, and associated morbidity compared with continuous gastric feeding (C\u2010GF). This study compared the effectiveness and safety of C\u2010GF vs B\u2010GF in intubated pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled randomized patients aged 1 month\u201312\u00a0years who were intubated within 24\u00a0hours and received EN starting within 48 hours of admission to a C\u2010GF or B\u2010GF group. Goal\u2010directed EN volume and caloric density were increased every 3 and 12 hours, respectively, to target. Feeding interruptions and intolerance events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five subjects were enrolled (B\u2010GF\u00a0=\u00a011; C\u2010GF\u00a0=\u00a014). At 24\u00a0hours, B\u2010GF was associated with higher energy and protein delivery (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.007) and was associated with faster time to goal volume (median B\u2010GF\u00a0=\u00a015\u00a0hours; C\u2010GF\u00a0=\u00a029.5\u00a0hours). No aspiration events resulting in additional lung injury were noted for either group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.866).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>B\u2010GF was associated with superior delivery of EN with a comparable safety profile to C\u2010GF. Further study is needed to compare both EN methods in other PICU populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1495","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T05:26:29Z","timestamp":1545283589000},"page":"750-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bolus vs Continuous Nasogastric Feeds in Mechanically Ventilated Pediatric Patients: A Pilot Study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2905-6353","authenticated-orcid":false,"given":"Ann\u2010Marie","family":"Brown","sequence":"first","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing Emory University  Atlanta Georgia USA"},{"name":"Pediatric Intensive Care Unit Akron Children's Hospital  Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Fisher","sequence":"additional","affiliation":[{"name":"Nell Hodgson Woodruff School of Nursing Emory University  Atlanta Georgia USA"},{"name":"School of Nursing College of Health Professions The University of Akron  Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Akron Children's Hospital  Akron Ohio 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