{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:39:54Z","timestamp":1783690794689,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007350","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Salud\u20102015\u20102\u2010261765"],"award-info":[{"award-number":["Salud\u20102015\u20102\u2010261765"]}],"id":[{"id":"10.13039\/501100007350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/G15\/1462\u00a0from\u00a0IMSS"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G15\/1462\u00a0from\u00a0IMSS"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Retinopathy of prematurity (ROP) is a disorder of the retina of low\u2010birth\u2010weight preterm infants that potentially leads to blindness. Docosahexaenoic acid (DHA), is protective in experimental models, but its administration as part of parenteral nutrition has shown inconsistent results. We test the effect of enteral DHA to prevent ROP and\/or severity and to reduce hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a double\u2010blind parallel clinical trial. Preterm infants (n = 110; 55 per group) with birth weight &lt;1500 g but \u22651000 g were recruited in a neonatal intensive care unit. Infants were randomized to receive 75 mg of DHA\/kg\/d (DHA group) or high oleic sunflower oil (control group) for 14 days by enteral feeding. The effect of DHA was evaluated on any stage of ROP, severe ROP (stage \u22653) incidence, and hospital stay. Groups were compared with relative risk (RR) and 95% confidence interval (CI), Fisher's exact test, Student's <jats:italic>t<\/jats:italic>\u2010test, or Mann\u2010Whitney U\u2010test, as appropriate. Logistic regression was applied to adjust for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference between the DHA and control groups in ROP risk (RR for DHA = 0.79; 95% CI, 0.49\u20131.27; <jats:italic>P<\/jats:italic> = 0.33). However, patients who received DHA showed lower risk for stage 3 ROP (RR for DHA = 0.66; 95% CI, 0.44\u20130.99; <jats:italic>P<\/jats:italic> = 0.03). After adjusting for confounders, this decreased risk remained significant (adjusted odds ratio = 0.10; 95% CI, 0.011\u20130.886; <jats:italic>P<\/jats:italic> = 0.04). Hospital stay was similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enteral DHA may reduce the incidence of stage 3 ROP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1497","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T21:56:04Z","timestamp":1546811764000},"page":"874-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Enteral Docosahexaenoic Acid and Retinopathy of Prematurity: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-2077","authenticated-orcid":false,"given":"Mariela","family":"Bernabe\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Villegas\u2010Silva","sequence":"additional","affiliation":[{"name":"Neonatolog\u00eda Hospital Infantil de M\u00e9xico Federico G\u00f3mez  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Villavicencio\u2010Torres","sequence":"additional","affiliation":[{"name":"Oftalmolog\u00eda Pedi\u00e1trica General Hospital Centro M\u00e9dico Nacional La Raza Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Calder","sequence":"additional","affiliation":[{"name":"Human Development and Health Academic Unit Faculty of Medicine University of Southampton Southampton General Hospital  Southampton UK"},{"name":"National Institute for Health Research Southampton Biomedical Research Centre University Hospital Southampton National Health Service Foundation Trust and University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-4023","authenticated-orcid":false,"given":"Maricela","family":"Rodr\u00edguez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Maldonado\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Mac\u00edas\u2010Loaiza","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardia","family":"L\u00f3pez\u2010Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Inda\u2010Icaza","sequence":"additional","affiliation":[{"name":"Nutrici\u00f3n Universidad An\u00e1huac M\u00e9xico Campus Norte  Huixquilucan Estado de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cruz\u2010Reynoso","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Pediatr\u00eda Hospital de Gineco\u2010Obstetricia No.3 Centro M\u00e9dico Nacional La Raza Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2996"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.WHO | Vision impairment and blindness. 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