{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:13Z","timestamp":1786978033534,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : Although home parenteral nutrition (HPN) is lifesaving for patients with chronic intestinal failure (IF), long\u2010term use can be associated with complications such as infections, metabolic abnormalities, and IF\u2013associated liver disease (IFALD). The key to treatment of many of these complications is prevention. Guidelines recommend avoidance of overfeeding, use of oral\/enteral nutrition if possible, cyclic PN, and maintaining dose of soybean oil (SO) intravenous lipid emulsion (ILE) &lt;1 g\/kg\/day as preventive strategies for IFALD. Additionally, with development of IFALD, \u03c9\u20106\/\u03c9\u20103 polyunsaturated fatty acid ratio should be decreased in ILE. The newly available mixed\u2010oil (MO) ILE offers such an opportunity; however, there is a paucity of long\u2010term data available.\n                    <jats:italic>Methods<\/jats:italic>\n                    : The current study reports our long\u2010term experience with MO ILE use in HPN patients.\n                    <jats:italic>Results<\/jats:italic>\n                    : Seventeen patients (8 female and 9 male) with an average age of 47 \u00b1 12 years and median HPN duration of 4.6 years (1.1\u201332.1 years) have utilized MO ILE for &gt;12 months after being transitioned from SO ILE because of intolerance. Use of MO ILE allowed an increase in ILE energy from 8% \u00b1 8% to 22% \u00b1 8% while reducing dextrose energy from 66% \u00b1 8% to 54% \u00b1 5%, maintaining stability in alkaline phosphatase and triglyceride levels, and achieving improvement in aspartate aminotransferase, alanine aminotransferase, total bilirubin, and \u03b1\u2010tocopherol levels.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : In this HPN cohort with SO ILE intolerance, MO ILE was well tolerated and allowed an improvement in macronutrient composition while improving some liver parameters over a 12\u2010month period.\n                  <\/jats:p>","DOI":"10.1002\/jpen.1526","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T18:17:51Z","timestamp":1552414671000},"page":"301-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Long\u2010Term Use of Mixed\u2010Oil Lipid Emulsion in Soybean Oil\u2013Intolerant Home Parenteral Nutrition Patients"],"prefix":"10.1002","volume":"44","author":[{"given":"Manpreet S.","family":"Mundi","sequence":"first","affiliation":[{"name":"Division of Endocrinology Diabetes, Metabolism and Nutrition, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind R.","family":"Kuchkuntla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes, Metabolism and Nutrition, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley R.","family":"Salonen","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bonnes","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Hurt","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes, Metabolism and Nutrition, Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of General Internal Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Gastroenterology Hepatology and Nutrition University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2016.02.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617718472"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616663635"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115587018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.07.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(12)60229-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112450301"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.066"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-7-200004040-00003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1999.98925"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607182006004304"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.07.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclnm.2010.08.003"},{"issue":"6","key":"e_1_2_8_16_1","first-page":"015","article-title":"SMOFlipid versus intralipid in postoperative ICU patients","volume":"1","author":"Metry AA","year":"2014","journal-title":"Enliven J Anesth Crit Care Med"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32832e08e0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181de210c"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110363614"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.06.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117741870"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.04.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10014"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006911"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K229"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90486-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80064-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2578-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(76)90085-8"},{"issue":"35","key":"e_1_2_8_30_1","first-page":"1347","article-title":"Early use of cyclic TPN prevents further deterioration of liver functions for the TPN patients with impaired liver function","volume":"47","author":"Hwang TL","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.06.017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117742595"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1984.01390230060014"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115595977"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjpen.1526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.1526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpen.1526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.1526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:44:47Z","timestamp":1760867087000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.1526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jpen.1526"],"URL":"https:\/\/doi.org\/10.1002\/jpen.1526","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"assertion":[{"value":"2018-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}