{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:27Z","timestamp":1790621007319,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T00:00:00Z","timestamp":1555804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shire Human Genetic Therapies, Inc."}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Teduglutide reduces or eliminates parenteral support (PS) dependency in patients with short bowel syndrome (SBS). Recent post hoc analyses demonstrated that effects are correlated with baseline PS volume. We assessed the SBS\u2010related quality\u2010of\u2010life (QoL) impact of teduglutide, particularly whether improvements are greater among subgroups achieving more PS volume reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using phase 3 trial data of teduglutide in patients with SBS (NCT00798967), change in Short Bowel Syndrome\u2013Quality of Life (SBS\u2010QoL) scores from baseline were compared between teduglutide vs placebo in the overall population and subgroups classified by baseline PS volume requirement, disease etiology, and bowel anatomy. Generalized estimating equation models were fitted to assess impact of teduglutide on SBS\u2010related QoL using data from all visits, adjusted for baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 86 patients, 43 each were randomized to teduglutide or placebo (mean age: 51 vs 50 years, respectively). In adjusted analyses, teduglutide had a nonsignificant reduction (improvement) of \u22128.6 points (95% CI: 2.6 to \u221219.8) in SBS\u2010QoL sum score from baseline to Week\u201024 vs placebo. The impact of teduglutide varied by subgroup. Patients treated with teduglutide experienced significantly greater reductions in SBS\u2010QoL sum score at Week\u201024 vs placebo in 2 subgroups, ie, the third (highest) tertile baseline PS volume (\u221227.3, 95% CI: \u221250.8 to \u22123.7) and inflammatory bowel disease (IBD; \u221229.6, 95% CI: \u221246.3 to \u221212.9). Results were similar for SBS\u2010QoL subscale and item scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The impact of teduglutide treatment on SBS\u2010related QoL vs placebo varied among subgroups and was significant and most pronounced among patients with highest baseline PS volume requirement or IBD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1588","type":"journal-article","created":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T23:38:05Z","timestamp":1555889885000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal Failure"],"prefix":"10.1002","volume":"44","author":[{"given":"Kristina","family":"Chen","sequence":"first","affiliation":[{"name":"Shire Human Genetic Therapies, Inc. (a member of the Takeda group of companies)  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Mu","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jipan","family":"Xie","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc.  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha S.","family":"Kelkar","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc.  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Olivier","sequence":"additional","affiliation":[{"name":"Shire International GmbH (a member of the Takeda group of companies)  Zug Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Signorovitch","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle B.","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Crohn's & Colitis Foundation of America.Short Bowel Syndrome and Crohn's Disease.2013. Available at:http:\/\/www.crohnscolitisfoundation.org\/resources\/short-bowel-syndrome-and.html. 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