{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:09:31Z","timestamp":1790057371015,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether providing nutrition support is beneficial or deleterious during targeted temperature management (TTM) after cardiac arrest is unclear. We therefore performed a retrospective observational study to determine whether early nutrition was beneficial or deleterious during TTM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied patients admitted to our intensive care unit (ICU) between 2008 and 2014 after successfully resuscitated cardiac arrest. We compared the group given nutrition within 48 hours after ICU admission (E+ group) to the group given nutrition later on or not at all (E\u2010 group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 203 included patients, 143 were in the E+ group and 60 in the E\u2010 group. The E+ group had a significantly higher proportion of patients with a good 3\u2010month neurological outcome (42.7% vs 16.7%, <jats:italic>P<\/jats:italic> &lt; 0.001). The difference remained significant after adjustment on a propensity score (odds ratio, 3.47; 95% confidence interval, 1.48\u20138.14; <jats:italic>P<\/jats:italic> = 0.004). The cumulative energy deficit for an energy goal of 20 kcal\/kg\/d from admission to day 7 was significantly lower in the E+ group (3304 \u00b1 2863 kcal vs 5017 \u00b1 2655 kcal, <jats:italic>P<\/jats:italic> &lt; 0.001). Within the E+ group, the subgroups with nutrition initiation when body temperature was &lt;36\u00b0C vs \u226536\u00b0C were not significantly different regarding the frequencies of early\u2010onset pneumonia, ventilator\u2010associated pneumonia, vomiting, and prokinetic drug use (all <jats:italic>P<\/jats:italic>\u2010values &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early nutrition after cardiac arrest during TTM appears safe and may be associated with better neurological outcomes. These findings warrant a randomized controlled trial to resolve the remaining issues.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1596","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T04:26:56Z","timestamp":1555907216000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Nutrition During Targeted Temperature Management After Cardiac Arrest: Observational Study of Neurological Outcomes and Nutrition Tolerance"],"prefix":"10.1002","volume":"44","author":[{"given":"Maelle","family":"Martin","sequence":"first","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation University Hospital Centre  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Reignier","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation University Hospital Centre  Nantes 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