{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:30:22Z","timestamp":1760920222706,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 GM122069","K23 HL139987","P01 HL114453"],"award-info":[{"award-number":["K23 GM122069","K23 HL139987","P01 HL114453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010554","name":"Clinical and Translational Science Institute, University of Pittsburgh","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010000005"],"award-info":[{"award-number":["UL1\u2010TR\u2010000005"]}],"id":[{"id":"10.13039\/100010554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sepsis is characterized by life\u2010threatening organ dysfunction caused by a dysregulated host response to infection and affects over 1 million Americans annually. Loss of glycemic control in sepsis is associated with increased morbidity and mortality, and novel approaches are needed to promote euglycemia and improve outcomes in sepsis. Recent studies from our laboratory demonstrate that early low\u2010level enteral dextrose infusion in septic mice attenuates the systemic inflammatory response and improves glycemic control by inducing intestine\u2010derived incretin hormone secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the Study of Early Enteral Dextrose in Sepsis (SEEDS) is to test the effect of a 24\u2010hour enteral dextrose infusion in critically ill septic patients as a therapeutic agent to decrease systemic inflammation and promote euglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SEEDS is a single\u2010center, double\u2010blind, randomized, controlled trial that will enroll 60 septic patients admitted to the intensive care units at the University of Pittsburgh Medical Center Health System in Pittsburgh. Participants will be randomized 1:1 to receive enteral dextrose (n\u00a0=\u00a030) or water (placebo, n\u00a0=\u00a030) infusion for 24 hours. The primary outcome is the circulating interleukin\u20106 level measured after the 24\u2010hour infusion compared between dextrose and placebo groups. Secondary outcomes include postinfusion circulating insulin, incretin, and other proinflammatory cytokine levels, as well as incidence of hyperglycemia and hypoglycemia during the infusion period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This trial will characterize the effects of early enteral dextrose on endogenous endocrine pathways and the systemic inflammatory response in sepsis. The results of this trial will inform future larger interventional studies of early enteral nutrients in critically ill patients with sepsis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1608","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:45:00Z","timestamp":1559263500000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rationale for and Design of the Study of Early Enteral Dextrose in Sepsis: A Pilot Placebo\u2010Controlled Randomized Clinical Trial"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-7738","authenticated-orcid":false,"given":"Faraaz Ali","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Pulmonary Allergy, and Critical Care Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Veteran Affairs Pittsburgh Healthcare System  Pittsburgh Pennsylvania 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