{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:11:55Z","timestamp":1784286715869,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with short bowel syndrome (SBS) receiving home parenteral nutrition (HPN) are predisposed to ambulatory central line\u2013associated bloodstream infection (A\u2010CLABSI). Data describing risk factors of this infection in children are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort, single\u2010center, case\u2010crossover study of children \u226418 years old with SBS receiving HPN from January 2012 to December 2016. Univariate and multivariate mixed effect Poisson regression identified the relative risk (RR) of A\u2010CLABSI with proposed risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five children were identified; median follow\u2010up was 30 months. A\u2010CLABSI rate was 4.2 per 1000 central line (CL) days. Univariate analysis identified younger age (RR: 0.92 per 12\u2010month increase [95% confidence interval {CI}: 0.85\u20100.99; <jats:italic>P<\/jats:italic> = 0.036]), shorter small intestine length (RR: 0.96 per 10\u2010cm increase [95% CI: 0.92\u20100.99; <jats:italic>P<\/jats:italic> = 0.008]), lower citrulline level (RR: 0.86 per 5\u2010nmol\/mL increase [95% CI: 0.75\u20100.99; <jats:italic>P<\/jats:italic> = 0.036]), and recent CL break (RR: 1.55 [95% CI: 1.06\u20102.28; <jats:italic>P<\/jats:italic> = 0.024]) as risk factors for A\u2010CLABSI. Multivariate analysis showed increased A\u2010CLABSI with clinical diagnosis of small intestine bacterial overgrowth (SIBO) (RR: 1.87 [95% CI: 1.1\u20103.17; <jats:italic>P<\/jats:italic> = 0.021]) and CL breaks (RR: 1.49 [95% CI: 1\u20102.22; <jats:italic>P<\/jats:italic> = 0.024]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Factors influencing gut integrity increase A\u2010CLABSI rate, supporting translocation as an important mechanism and target for prevention. Clinical diagnosis of SIBO increases A\u2010CLABSI rate, but whether dysbiosis or diarrhea is responsible is an area for future research. CL maintenance is crucial, and prevention of breaks would likely decrease A\u2010CLABSI rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1667","type":"journal-article","created":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T21:24:02Z","timestamp":1560115442000},"page":"500-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Risk Factors of Ambulatory Central Line\u2013Associated Bloodstream Infection in Pediatric Short Bowel Syndrome"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-4160","authenticated-orcid":false,"given":"Talal B.","family":"Seddik","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Biomedical Data Science\u2010Administration Stanford University  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