{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:06:25Z","timestamp":1789517185572,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T00:00:00Z","timestamp":1566086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Teduglutide response, in terms of parenteral support (PS) volume reduction, is associated with specific disease characteristics among adults with short bowel syndrome\u2013associated intestinal failure (SBS\u2010IF). Whether these associations apply to PS weaning with teduglutide is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Adults with SBS\u2010IF treated with teduglutide in the phase III STEPS study and open\u2010label extensions STEPS\u20102 and STEPS\u20103 were included in the analysis. Patients required PS \u2265 3 times weekly for \u2265 12 months at enrollment. The study population was stratified 3 times to create 3 distinct analysis populations based on bowel anatomy, etiology, and baseline PS volume. Outcomes included characteristics of patients who achieved PS independence and total and percentage of patients who had \u2265 1, \u2265 2, and \u2265 3 d\/wk off PS at the end of STEPS, STEPS\u20102, and STEPS\u20103.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Eight of 39 patients who received teduglutide in STEPS obtained PS independence during the STEPS study series. Patients required > 6 months of teduglutide treatment before enteral autonomy was achieved, regardless of underlying disease characteristics. Patients who attained PS independence and greater numbers of days per week off PS tended to have lower baseline PS volumes and noninflammatory bowel disease (non\u2010IBD) etiology. Patients with \u2265 50% colon\u2010in\u2010continuity showed a trend for achieving greater numbers of days per week off PS.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although this analysis was limited by low patient numbers, results suggest that SBS\u2010IF characteristics of lower baseline PS volume and non\u2010IBD etiology were associated with PS reduction benefits with teduglutide in terms of days off per week and enteral autonomy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jpen.1687","type":"journal-article","created":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T21:14:27Z","timestamp":1566162867000},"page":"697-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5748-2547","authenticated-orcid":false,"given":"Douglas L.","family":"Seidner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Hepatology and Nutrition Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Gabe","sequence":"additional","affiliation":[{"name":"Lennard Jones Intestinal Failure Unit St. Mark's Hospital, Northwick Park London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak\u2010Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Shire Human Genetic Therapies, Inc., Lexington, MA, USA, a member of the Takeda group of companies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Olivier","sequence":"additional","affiliation":[{"name":"Shire International GmbH, Zug, Switzerland, a member of the Takeda group of companies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle Bekker","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114520994"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113520005"},{"key":"e_1_2_9_5_1","volume-title":"Full Prescribing Information","author":"GATTEX (teduglutide","year":"2019"},{"key":"e_1_2_9_6_1","volume-title":"Full Prescribing Information","author":"Revestive 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