{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:21:54Z","timestamp":1791390114097,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with short bowel syndrome (SBS) are dependent on parenteral nutrition (PN) while their bowel attempts to compensate. Our objective was to create an SBS disease severity score to predict the probability of achieving enteral autonomy (EA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of children with SBS managed by our Intestinal Rehabilitation Program was completed. Data abstracted included demographic, bowel anatomy, and outcome variables including conjugated bilirubin (CB) and enteral nutrition (EN) tolerated 6 months postoperatively. Univariate analysis and Cox proportional hazards (CPH) model were performed. A score was created based on weighting of coefficients. An \u03b1\u2010value of &lt; 0.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010nine patients were analyzed (61% males). Ninety\u2010five (68%) achieved EA. Patients possessing &gt;50% residual small bowel (hazard ratio [HR] 2.68 [95% confidence interval {CI} 1.60\u20104.49], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), ileocecal valve intact (HR 0.61 [95% CI 0.37\u20101.01], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.055), and &gt;50% enteral tolerance at 6 months (HR 5.70 [95% CI 2.77\u201011.74] <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were positively associated with EA. CB &gt;34 \u00b5mol\/L (2 mg\/dL) was negatively associated with EA (HR 0.42 [95% CI0.27\u20100.66], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). A severity score was created by weighting CPH parameter estimates (small bowel length &gt;50%, ileocecal valve intact, CB &lt;34 \u00b5mol\/L, and EN &gt;50% for a maximum score of 8), and disease severity strata were developed (severe [25.7% EA], moderate [52.9% EA], and mild [97.1% EA]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose a pediatric SBS disease severity score that predicts probability of EA. The score allows prognostication of individual patients and could assist research by adjusting outcome reporting or stratifying recruitment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1691","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T23:13:41Z","timestamp":1567034021000},"page":"961-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Early Predictors of Enteral Autonomy in Pediatric Intestinal Failure Resulting From Short Bowel Syndrome: Development of a Disease Severity Scoring Tool"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-295X","authenticated-orcid":false,"given":"Christina","family":"Belza","sequence":"first","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"de Silva","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Avitzur","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment University of Toronto  Toronto Canada"},{"name":"Division of Gastroenterology, Hepatology and Nutrition University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Wales","sequence":"additional","affiliation":[{"name":"Group for Improvement of Intestinal Function and Treatment University of Toronto  Toronto Canada"},{"name":"Division of General and Thoracic Surgery The Hospital for Sick Children University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12159.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40836.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.036"},{"key":"e_1_2_8_5_1","article-title":"Predicting Intestinal Adaptation in Pediatric Intestinal Failure: A Retrospective Cohort Study","author":"Belza C","year":"2017","journal-title":"Ann 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