{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:32:42Z","timestamp":1789749162191,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine whether parenteral plus enteral glutamine supplementation influences microbial invasion in surgical infants who require parenteral nutrition (PN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An prospective double\u2010blind randomized controlled trial studying surgical infants receiving PN for at least 5\u00a0days for congenital or acquired intestinal anomalies (2009\u20132012) was used. Infants were randomized to receive either glutamine supplementation (parenteral plus enteral; total 400\u00a0mg\/kg\/d) or isonitrogenous control. The primary end point was microbial invasion evaluated after 5\u00a0days of supplementation and defined as: (i) positive conventional blood culture, (ii) evidence of microbial DNA in blood (polymerase chain reaction), (iii) plasma endotoxin level \u226550 pg\/mL, or (iv) plasma level of lipopolysaccharide binding protein \u226550 ng\/mL. Data are given as median (range) and compared by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty infants were randomized and reached the primary end point. Twenty\u2010five patients had intestinal obstruction, 19 had abdominal wall defects, and 13 had necrotizing enterocolitis. Thirty\u2010six infants showed evidence of microbial invasion during the study, and 17 of these were not detected by conventional blood culture. There was no significant difference between the 2 groups in the primary outcome; evidence of microbial invasion after 5\u00a0days was found in 9\/31 (control group) and 8\/29 (glutamine group) (odds ratio 0.83 [0.24\u20132.86; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.77]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than half of surgical infants requiring PN showed evidence of microbial invasion. Approximately half of this was not detectable by conventional blood cultures. Parenteral plus enteral glutamine supplementation had no effect on incidence of microbial invasion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1700","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T23:34:46Z","timestamp":1568072086000},"page":"80-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Glutamine Supplementation on Microbial Invasion in Surgical Infants Requiring Parenteral Nutrition: Results of a Randomized Controlled Trial"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-5151","authenticated-orcid":false,"given":"Mark","family":"Bishay","sequence":"first","affiliation":[{"name":"University College of London Great Ormond Street Institute of Child Health  London United Kingdom"},{"name":"Great Ormond Street Hospital for Children  London United 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