{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:47:01Z","timestamp":1779115621571,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Weaning from parenteral support is considered indirect evidence of intestinal adaptation in patients with short bowel syndrome (SBS), but direct evidence is lacking. The objective of this study was to examine if intestinal adaptation could be demonstrated as increase in intestinal absorption of energy and wet weight over time measured by repeated metabolic balance studies (MBSs) and to examine whether adaptation was determined by the anatomy of the remnant bowel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data from 48 repeated MBSs performed in 13 adult patients with SBS. Results were presented graphically and interpreted. The interpatient and intrapatient heterogeneity was compared based on anatomy of the remnant bowel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of repeated MBSs ranged from 2 to 7, and time between last intestinal resection and MBS from 5 months to 18.1\u00a0years. In 6 patients, the first MBS was performed within 2\u00a0years after last resection, but only 1 patient had repeated MBSs within this period. Nine patients had an end jejunoileostomy, and 4 patients had a jejuno\u2010colonic or ileo\u2010colonic anastomosis. None of the patients had jejunoileal anastomosis with a preserved ileocecal valve. Interpatient and intrapatient heterogeneity of wet weight and energy absorption was larger in patients without colon in continuity. The wet weight and energy absorption data showed no tendency toward intestinal adaptation in any anatomical group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed no signs of late\u2010phase intestinal adaptation in this selected group of patients with SBS. Future prospective MBSs are needed to understand the time course and magnitude of intestinal adaptation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1704","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:19:30Z","timestamp":1568006370000},"page":"677-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Repeated Metabolic Balance Studies in Patients With Short Bowel Syndrome"],"prefix":"10.1002","volume":"44","author":[{"given":"Haifeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-9182","authenticated-orcid":false,"given":"Johanna","family":"Eliasson","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian A.","family":"Fuglsang","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hvistendahl","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahim M.","family":"Naimi","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palle B.","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology  Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"128","article-title":"Resection de deux metres d'intestin grele","volume":"45","author":"Koeberle E","year":"1881","journal-title":"Bull Acad de Med"},{"key":"e_1_2_8_3_1","first-page":"527","article-title":"Experimentelle Untersuchungen uber die Kompensatorischen Vorgange bei Darmresektionen","volume":"89","author":"Stassoff B","year":"1914","journal-title":"Beitr Klin Chir"},{"key":"e_1_2_8_4_1","first-page":"478","article-title":"Compensatory mechanisms following massive small bowel resection for intestinal volvulus","volume":"109","author":"Butler DB.","year":"1959","journal-title":"Surg Gynecol Obstet."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(65)80064-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1969.01340170012003"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"1455","article-title":"Histological findings regarding jejunal mucosa in short bowel syndrome","volume":"26","author":"De Francesco A","year":"1994","journal-title":"Transplant Proc."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)36599-0"},{"issue":"7455","key":"e_1_2_8_9_1","first-page":"146","article-title":"Functional compensation after small\u2010bowel resection in man. 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