{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:11:22Z","timestamp":1760868682513,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Poor nutrition status is common among hospitalized children and children in low\u2010income countries and may be associated with increased susceptibility to edema and infections. We hypothesized that poor nutrition status, established with a suboptimal composition of parenteral nutrition (PN), predisposes to endotoxemia\u2010induced edema, oxidative stress, and dysregulated immune responses. <jats:italic>Methods<\/jats:italic>: Using a 2 \u00d7 2 factorial design, 3\u2010day\u2010old piglets (n = 40) were given either optimal or suboptimal composition of PN for 7\u00a0days and then infused with either saline or lipopolysaccharide (LPS) for 9\u00a0hours to induce an acute\u2010phase reaction. Abdominal tissue edema and blood markers of immunity, inflammation, and oxidative stress were assessed. <jats:italic>Results<\/jats:italic>: Piglets receiving suboptimal nutrition showed signs of malnutrition with restricted growth, signs of inflammation (elevated C\u2010reactive protein [CRP], interleukin\u20106, and serum amyloid A levels), oxidative stress (lower erythrocyte glutathione\/hemoglobin and \u03b1\u2010tocopherol\/cholesterol ratios), and liver dysfunction (increased liver weight and blood bilirubin levels). Perirenal edema was more excessive in malnourished LPS\u2010infused animals, relative to healthy LPS\u2010infused control animals (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01). Malnutrition reduced the inflammatory response to LPS (lower CRP, tumor necrosis factor\u2010\u03b1, haptoglobin, and neutrophil to lymphocyte ratio) but did not influence LPS\u2010induced oxidative stress markers. <jats:italic>Conclusions<\/jats:italic>: We conclude that endotoxemia and malnutrition in combination lead to acute\u2010phase hyporesponsiveness and perirenal edema in piglets. This finding may have implications for pediatric patients that suffer from malnutrition, as their response to bacterial infections may differ substantially from patients of normal nutrition status.<\/jats:p>","DOI":"10.1002\/jpen.1705","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T22:13:40Z","timestamp":1568240020000},"page":"668-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Malnutrition Predisposes to Endotoxin\u2010Induced Edema and Impaired Inflammatory Response in Parenterally Fed Piglets"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-0952","authenticated-orcid":false,"given":"Ole","family":"B\u00e6k","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Fabiansen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ritz","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob L.","family":"Willesen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M. 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