{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:36:25Z","timestamp":1791412585254,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonates have limited antioxidative capacity and are at increased risk of infection and inflammation\u2014a situation that is exacerbated in preterm neonates. Together, oxidative stress and inflammation are implicated in many serious conditions affecting neonates, such as bronchopulmonary dysplasia and periventricular leukomalacia. Neonates requiring parenteral nutrition have certain nutritional requirements. For example, very long\u2010chain \u03c9\u20103 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are regarded as conditionally essential with critical roles during early retinal and brain development, and may also have other benefits such as anti\u2010inflammatory effects. Because of these factors, the choice of lipid emulsion used as part of parenteral nutrition support may influence clinical outcomes in neonates. There are concerns that lipid emulsions based purely on soybean oil may increase lipid peroxidation, oxidative stress, and inflammation because of their high \u03c9\u20106 PUFA and low \u03c9\u20103 PUFA concentrations. Composite fish\u2010oil containing lipid emulsions may provide advantages for neonates owing to their high DHA and EPA content and high antioxidant (\u03b1\u2010tocopherol) levels. Here, we discuss clinical trials of lipid emulsions in preterm and term neonatal populations, with a particular emphasis on markers of oxidative stress and DHA and EPA levels. Olive oil\/soybean oil lipid emulsions have shown few advantages in neonates over other lipid emulsions. However, compared with either pure soybean or soybean\/olive\u2010oil based emulsions, composite fish\u2010oil containing lipid emulsions reduce oxidative stress\/lipid peroxidation and also increase DHA and EPA levels. These advantages may translate into clinical benefits for neonates requiring parenteral nutrition.<\/jats:p>","DOI":"10.1002\/jpen.1759","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T11:22:50Z","timestamp":1581506570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Use of Lipids in Neonates Requiring Parenteral Nutrition"],"prefix":"10.1002","volume":"44","author":[{"given":"Girish C.","family":"Deshpande","sequence":"first","affiliation":[{"name":"Neonatal NICU, Nepean Hospital  Kingswood NSW Australia"},{"name":"Sydney Medical School Nepean, University of Sydney  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Division of Pediatric Gastroenterology and Nutrition Xin Hua Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1746"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.946"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2005.tb00011.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.08.032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040388"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08124.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607106030004351"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2006500"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000174"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060776"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819ca1b8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004230100241"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112467821"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.08.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365426"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1385-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20160474"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.08.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358466"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.048"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1597131"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.204974"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13798"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13120.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087586"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320159"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08135.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075813"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.05.004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.06.018"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03335.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500500216546"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-005-1460-7"},{"key":"e_1_2_7_36_1","unstructured":"DeshpandeG RakshasbhuvankarA SimmerK MoriT CroftK CurrieA.Efficacy and safety of a novel fish oil based emulsion (SMOFlipid\u00ae) compared with olive oil based lipid emulsion (ClinOleic\u00ae) in term and near\u2010term (>34 weeks) surgical neonates\u2014a randomised controlled trial. 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