{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:20:29Z","timestamp":1780489229589,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although adaptive mucosal growth of the remaining small intestine is an essential compensatory mechanism to bowel resection in experimental short\u2010bowel syndrome (SBS), only scarce clinical data are available. We studied structural and molecular mechanisms of intestinal adaptation in children with SBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>: Fourteen patients, who had been dependent on parenteral nutrition (PN) since neonatal period for a median (interquartile range)1.4 (0.7\u20136.5) years, were studied at the age of 1.5 (1.0\u20136.5) years. Median length of remaining small bowel was 33 (12\u201360) cm, and 6 patients had their ileocecal valve preserved. Six children without gastrointestinal disorders served as age\u2010matched and gender\u2010matched controls. All patients underwent duodenal biopsies. Mucosal microarchitecture, proliferation, apoptosis, inflammation, and epithelial\u2010barrier function were addressed using histology, immunohistochemistry, and quantitative real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>: Villus height, crypt depth, enterocyte proliferation, and apoptosis were similar in patients and matched controls. Messenger RNA (mRNA) expression of numerous genes regulating gut epithelial\u2010barrier function (<jats:italic>TGFB2, CAV1<\/jats:italic>, <jats:italic>CLDN1<\/jats:italic>, <jats:italic>MUC2<\/jats:italic>, and <jats:italic>NLRC4<\/jats:italic>) was significantly altered. Of various nutrient transporters studied, only expression of <jats:italic>SLC2A1<\/jats:italic> encoding facilitative glucose transporter <jats:italic>GLUT1<\/jats:italic> was increased among patients, whereas RNA expression of genes encoding sodium\u2010dependent glucose, sterol, fatty\u2010acid, and peptide transport remained unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>: Duodenal mucosal hyperplasia has a limited role in mediating physiological adaptation following intestinal resection among PN\u2010dependent children with SBS. Further clinical studies addressing functional significance of the observed alterations in mucosal RNA expression are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1763","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T10:49:24Z","timestamp":1580122164000},"page":"1291-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parenteral Nutrition\u2013Dependent Children With Short\u2010Bowel Syndrome Lack Duodenal\u2010Adaptive Hyperplasia but Show Molecular Signs of Altered Mucosal Function"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-2609","authenticated-orcid":false,"given":"Galina","family":"Sanaksenaho","sequence":"first","affiliation":[{"name":"Section of Pediatric Surgery Pediatric Liver and Gut Research Group Pediatric Research Center Children's Hospital University of Helsinki and Helsinki University Hospital  Helsinki 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