{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:47Z","timestamp":1790621027817,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Zealand Pharma"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with short bowel syndrome (SBS) and distal\u2010bowel resections lack neuroendocrine feedback regulations, potentially resulting in rapid gastrointestinal (GI) transit. The objective was to assess the efficacy of glepaglutide, a long\u2010acting glucagon\u2010like peptide\u20102 analog, on GI transit in patients with SBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, double\u2010blind, dose\u2010finding, phase 2 trial, patients with SBS were randomly assigned to 3 treatments (0.1, 1, and 10\u00a0mg) in a 2\u2010period crossover design. Each treatment period included 3\u00a0weeks of daily, subcutaneous glepaglutide injections separated by a washout period of 4\u20138\u00a0weeks. Endpoints were changes from baseline and included scintigraphy, wireless motility capsule (WMC, SmartPill Given Imaging, Ltd, Yokneam, Israel), and paracetamol absorption test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 18 patients were randomized. In the 10\u2010mg dose group (n = 9), glepaglutide significantly increased time to 10% gastric emptying (GE) of solids by 27 (4\u201350) minutes (adjusted mean [95% CI]), time to 50%GE of fluids by 40 (1\u201380) minutes, and time to 10% small bowel\u2013emptying of solids by 21 (1\u201341) minutes. The WMC transit did not significantly change in any of the dose groups. The maximum paracetamol concentration significantly increased in the 10\u2010mg dose group; however, the area under the curve remained the same.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prolonged GI transit after glepaglutide treatment, along with demonstrated positive effects on intestinal mucosal growth and potential effects on GI hypersecretions, is believed to contribute to the observed beneficial effects on fecal output (primary endpoint) and associated improvement in intestinal absorption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.1767","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T05:54:02Z","timestamp":1580882042000},"page":"1535-1544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Effect of Glepaglutide, a Long\u2010Acting Glucagon\u2010Like Peptide\u20102 Analog, on Gastrointestinal Transit Time and Motility in Patients With Short Bowel Syndrome: Findings From a Randomized Trial"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-4819","authenticated-orcid":false,"given":"Mark Krogh","family":"Hvistendahl","sequence":"first","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahim Mohammad","family":"Naimi","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte Hahn","family":"Enevoldsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Nuclear Medicine and PET Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Lysgaard","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Centre for Functional and Diagnostic Imaging and Research Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fuglsang","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Centre for Functional and Diagnostic Imaging and Research Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle Bekker","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology and Hepatology Rigshospitalet University of Copenhagen  Copenhagen 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