{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:17:29Z","timestamp":1791490649929,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parenteral nutrition (PN) is critical for the growth and development of premature neonates who are unable to reach nutrition goals enterally. Using soybean\u2010oil emulsions in PN is a risk factor for cholestasis, leading to alternative dosing strategies including a reduction in total lipid prescribed. Recently, SMOFlipid has been utilized with the goal of avoiding cholestasis while maintaining energy intake. The aim of our study was to compare the incidence of PN\u2010associated cholestasis (PNAC) in patients admitted to the neonatal intensive care unit (NICU) who received either Intralipid 20% or SMOFlipid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, retrospective study evaluated all NICU patients who received PN for \u226514\u00a0days. Patients who received SMOFlipid were compared with those who received Intralipid. The primary end point was incidence of PNAC. Secondary end points included (1) prevalence of elevated liver function tests; (2) effect on select laboratory parameters; (3) development of PNAC by age; and (4) incidence of retinopathy of prematurity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 136 neonates were included. Nine of 55 patients (16.4%) in the Intralipid group and 2 of 81 patients (2.5%) in the SMOFlipid group developed cholestasis, defined as\u00a0direct bilirubin &gt; 2\u00a0mg\/dL\u00a0or direct bilirubin &gt; 20% of total bilirubin,\u00a0when total bilirubin is &gt;5\u00a0mg\/dL,\u00a0on or before 30\u00a0days post initiation of PN (<jats:italic>P<\/jats:italic> = .007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of SMOFlipid as the lipid emulsion component of PN may be beneficial in prevention of PNAC in NICU patients that are receiving PN for \u22652 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1843","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T07:47:30Z","timestamp":1589183250000},"page":"339-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["SMOFlipid vs Intralipid 20%: Effect of Mixed\u2010Oil vs Soybean\u2010Oil Emulsion on Parenteral Nutrition\u2013Associated Cholestasis in the Neonatal Population"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-3340","authenticated-orcid":false,"given":"Rachel Leigh","family":"Jackson","sequence":"first","affiliation":[{"name":"Intermountain Healthcare, Utah Valley Hospital  Provo Utah USA"},{"name":"Intermountain Healthcare, Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip Zachary","family":"White","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Utah Valley Hospital  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Zalla","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare, Utah Valley Hospital  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0796"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MPG.0000000000001334","article-title":"Guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN)","volume":"64","author":"Fawaz R","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.14-2-e63"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.11.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2015.06.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3389-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.11.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2016.08.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70082-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.238S"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665107005666"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007427"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.047"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114527772"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.02.006"},{"key":"e_1_2_9_17_1","unstructured":"Drugs@FDA.Food and Drug Administration (US) Center for Drug Evaluation and Research. 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