{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:36:21Z","timestamp":1769823381394,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is challenging to provide optimum nutrition in low\u2010birth\u2010weight (LBW) infants with short\u2010bowel syndrome (SBS) and ostomy. This study aims to evaluate the clinical course of LBW infants with SBS and ostomy in response to enteral feeds, recognize characteristics associated with achievement of enteral autonomy prior to reanastomosis, and evaluate associated short\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 52 LBW neonates with intestinal failure (IF) caused by SBS and ostomy treated in a neonatal intensive care unit from 2012 to 2018 was performed. Clinical characteristics and short\u2010term outcomes were studied in relation to the location of the ostomy and the success with enteral feeding achieved prior to reanastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 52 infants with SBS, jejunostomy, ileostomy, and colostomy were present in 9, 40, and 3 infants, respectively. Fourteen (26.92%) infants achieved enteral autonomy transiently, and 7 (13.46%) sustained until reanastomosis. All 9 infants with jejunostomy were parenteral nutrition dependent, compared with 22 with ileostomy and none with colostomy (<jats:italic>P<\/jats:italic> = 0.002). Infants who achieved enteral autonomy showed lower incidence of cholestasis (<jats:italic>P<\/jats:italic> = 0.038) and better growth velocity (<jats:italic>P<\/jats:italic> = 0.02) prior to reanastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A minority of LBW infants with SBS and ostomy achieved enteral autonomy prior to reanastomosis. Distal ostomy (ileostomy and colostomy), reduced cholestasis, and better growth were associated with achievement of enteral autonomy. Our report highlights the challenges in establishing enteral autonomy in LBW infants with IF and ostomy, and the feasibility of that approach in a minority of patients, with tangible benefits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1847","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T08:16:07Z","timestamp":1588580167000},"page":"331-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Small Proportion of Low\u2010Birth\u2010Weight Infants With Ostomy and Intestinal Failure Due to Short\u2010Bowel Syndrome Achieve Enteral Autonomy Prior to Reanastomosis"],"prefix":"10.1002","volume":"45","author":[{"given":"Anne L.","family":"Smazal","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Neonatology Baylor College of Medicine Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Adriana","family":"Massieu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Services Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gollins","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Services Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Hagan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Neonatology Baylor College of Medicine Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy B.","family":"Hair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Neonatology Baylor College of Medicine Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-9354","authenticated-orcid":false,"given":"Muralidhar H.","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Neonatology Baylor College of Medicine Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12159.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3449"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211686"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602650"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-312917"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_8_9_1","unstructured":"WHO Growth Charts.Centers for Disease Control and Prevention. 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