{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:45:51Z","timestamp":1760921151617,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In treating short\u2010bowel syndrome (SBS), autonomy from parenteral nutrition (PN) relies upon intestinal adaptation, which can be augmented by glucagon\u2010like peptide\u20102 (GLP\u20102) analogues. In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP\u20102 analogues: teduglutide (TED) and apraglutide (APRA)<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following 75% distal small\u2010intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg\/kg\/dose; n = 8), and TED once daily (TED, 0.05 mg\/kg\/dose; n = 8) or twice daily (TEDBID, 0.05 mg\/kg\/dose; n = 7). Pharmacokinetic (PK) studies were undertaken, and on day 7, small\u2010intestinal length and weight were measured and jejunal tissue collected for histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PK profiles were different between the 2 analogues. To achieve a comparable exposure to APRA, TED requires twice daily injection (TEDBID). Compared with CON, APRA and TEDBID increased small\u2010bowel length (cm) (CON: 141, APRA: 166, TED: 153, TEDBID: 165; <jats:italic>P<\/jats:italic> = .004), whereas APRA increased small\u2010bowel weight (g) (CON: 26, APRA: 33, TED: 28, TEDBID: 31; <jats:italic>P<\/jats:italic> = .007) and villus height (mm) (CON: 0.59, APRA: 0.90, TED: 0.58, TEDBID: 0.74; <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>APRA injected only twice during the 7 consecutive days demonstrated a superior intestinotrophic effect compared with TED injected once daily. Even at more comparable drug exposure, when TED was injected twice a day, APRA showed superior trophic activity at the mucosal level. This is highly relevant for the treatment of pediatric SBS, given the markedly lower dose frequency by subcutaneous injection of APRA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1853","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T11:08:27Z","timestamp":1590059307000},"page":"538-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparing the Intestinotrophic Effects of 2 Glucagon\u2010Like Peptide\u20102 Analogues in the Treatment of Short\u2010Bowel Syndrome in Neonatal Piglets"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8700-0035","authenticated-orcid":false,"given":"Mirielle L.","family":"Pauline","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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