{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:43:40Z","timestamp":1787161420449,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Severe gastrointestinal dysmotility disorder (GID) constitute approximately 20% of patients requiring home parenteral nutrition (HPN), whereas short\u2010bowel syndrome (SBS) remains the most frequent indication for HPN. This study's aim was to characterize GID patients and compare clinical parameters and survival to SBS patients. Similarly, clinical comparisons between sclerodermaand nonscleroderma patients were made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic and clinical data for all patients was extracted from the Canadian HPN Registry from January 1, 2003, to November 1, 2018. Kaplan\u2010Meier method was used to estimate the unadjusted survival probability, and log\u2010rank test was used to compare the survival probability between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      270 patients (52 GID and 218 SBS) were included in the analysis. For all patients, higher mortality was associated with age (hazard ratio [HR], 1.02 [1.00\u20131.04];\n                      <jats:italic>P<\/jats:italic>\n                      = .05), PN dependence (HR, 1.01 [1.00\u20131.02];\n                      <jats:italic>P<\/jats:italic>\n                      = .04), hospitalizations (HR, 1.21 [1.10\u20131.33];\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), and use of immunosuppressant (HR, 1.97 [1.02\u20133.82];\n                      <jats:italic>P<\/jats:italic>\n                      = .04). The 5\u2010 and 10\u2010year actuarial survival probabilities between GID and SBS were not significantly different (5\u2010year: 70.0% vs 59.2%; 10\u2010year: 79.6% vs 66.2% [\n                      <jats:italic>P<\/jats:italic>\n                      = .5], respectively). There was no difference in survival between scleroderma and nonscleroderma patients (\n                      <jats:italic>P<\/jats:italic>\n                      = .67).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T5\u2010 and 10\u2010 year survival probabilities were similar between GID and SBS patients. The diagnosis of scleroderma had no effect on survival. Use of immunosuppressant, older age, PN dependence, and number of hospitalizations per PN duration are risk factors for mortality in both the GID and SBS groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpen.1866","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T10:48:38Z","timestamp":1588934918000},"page":"530-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Patients With Severe Gastrointestinal Dysmotility Disorders Receiving Home Parenteral Nutrition Have Similar Survival As Those With Short\u2010Bowel Syndrome: A Prospective Cohort Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1731-3543","authenticated-orcid":false,"given":"Ennaliza","family":"Salazar","sequence":"first","affiliation":[{"name":"Toronto General Hospital University of Toronto  Toronto Canada"},{"name":"Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayima M.","family":"Clermont\u2010Dejean","sequence":"additional","affiliation":[{"name":"Toronto General Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J. P.","family":"Schwenger","sequence":"additional","affiliation":[{"name":"Toronto General Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5826-6229","authenticated-orcid":false,"given":"Jessica","family":"Noelting","sequence":"additional","affiliation":[{"name":"Toronto General Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Lu","sequence":"additional","affiliation":[{"name":"Dalla Lana Public Health Department University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Lou","sequence":"additional","affiliation":[{"name":"Dalla Lana Public Health Department University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-7059","authenticated-orcid":false,"given":"Johane P.","family":"Allard","sequence":"additional","affiliation":[{"name":"Toronto General Hospital University of Toronto  Toronto 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