{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:21:08Z","timestamp":1790018468690,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infants with gastroschisis require operations and lengthy hospitalizations due to intestinal dysmotility. Dysbiosis may contribute to these problems. Little is known on the microbiome of gastroschisis infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The purpose of this study was to investigate the fecal microbiome in gastroschisis infants. Microbiome profiling was performed by sequencing the V4 region of the 16S rRNA gene. The microbiome of gastroschisis infants was compared with the microbiome of healthy controls, and the effects of mode of birth delivery, gestational age, antibiotic duration, and nutrition type on microbial composition and diversity were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The microbiome of gastroschisis infants (n = 13) was less diverse (Chao1, <jats:italic>P<\/jats:italic> &lt; .001), lacked <jats:italic>Bifidobacterium<\/jats:italic> (<jats:italic>P<\/jats:italic> = .001), and had increased <jats:italic>Staphylococcus<\/jats:italic> (<jats:italic>P<\/jats:italic> = .007) compared with controls (n = 83). Mode of delivery (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.04, <jats:italic>P<\/jats:italic> = .001), antibiotics duration \u22657 days (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.03, <jats:italic>P<\/jats:italic> = .003), age at sample collection (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.03, <jats:italic>P<\/jats:italic> = .009), and gestational age (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.02, <jats:italic>P<\/jats:italic> = .035) explained a small portion of microbiome variation. In gastroschisis infants, <jats:italic>Escherichia\u2010Shigella<\/jats:italic> was the predominate genus, and those delivered via cesarean section had different microbial communities, predominantly <jats:italic>Staphylococcus<\/jats:italic> and <jats:italic>Streptococcus<\/jats:italic>, from those delivered vaginally. Although antibiotic duration contributed to the variation in microbiome composition, there were no significant differences in taxa distribution or \u03b1 diversity by antibiotic duration or nutrition type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The microbiome of gastroschisis infants is dysbiotic, and mode of birth delivery, antibiotic duration, and gestational age appear to contribute to microbial variation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1926","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T08:04:45Z","timestamp":1590134685000},"page":"818-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Clinical Factors on the Intestinal Microbiome in Infants With Gastroschisis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-5439","authenticated-orcid":false,"given":"Allison 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