{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:25Z","timestamp":1790621005377,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Teduglutide, a semisynthetic analogue of glucagon\u2010like peptide\u20102 (sGLP\u20102), increases intestinal absorption of fluids and nutrients, reducing the need for parenteral nutrition (PN). This report aims to describe our experience with sGLP\u20102 in a cohort of adult patients with short\u2010bowel syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective observational study on adult patients initially evaluated in our specialized intestinal rehabilitation program that received sGLP\u20102 from June 2014 to March 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Autologous gastrointestinal reconstruction surgery (AGIRS) was performed in 108 patients; 68.5% (74 of 108) achieved intestinal sufficiency with standard medical therapy. Seventeen patients were treated with sGLP\u20102; 66.5% (8 of 12) received treatment for a mean time of 25.8 weeks (3.4\u201354.0) and could suspend PN. One patient reinitiated treatment due to renal lithiasis and acute renal failure. Currently, 7 of 12 patients (53.8%) continue without PN for a mean time of 165.6 weeks. Volume, energy, and days of PN were reduced in all patients. No serious adverse events were registered. Four of 7 patients (57.1%) who discontinued PN could also discontinue sGLP\u20102. Therefore, the use of sGLP\u20102 increased the overall success rate of PN independency after AGIRS to 76% (82 of 108).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirmed that sGLP\u20102 should be considered as part of the standard therapy for postsurgical medical rehabilitation treatment in patients with chronic intestinal failure. We add to the current knowledge that some patients can discontinue both PN and sGLP\u20102 in the long term, achieving complete recovery of their quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1983","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T05:26:55Z","timestamp":1596346015000},"page":"1072-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Postsurgical Intestinal Rehabilitation Using Semisynthetic Glucagon\u2010Like Peptide\u20102 Analogue (sGLP\u20102) at a Referral Center: Can Patients Achieve Parenteral Nutrition and sGLP\u20102 Independency?"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-7073","authenticated-orcid":false,"given":"Hector","family":"Solar","sequence":"first","affiliation":[{"name":"Intestinal Failure, Rehabilitation and Transplant Unit, Favaloro Foundation University Hospital  Buenos Aires 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