{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:53Z","timestamp":1790621033605,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Survival of patients with short\u2010bowel syndrome (SBS) receiving home parenteral nutrition (HPN) and associated factors have not been reported recently in North America. The objective of this study was to determine the long\u2010term survival of adult patients with SBS as the primary indication for HPN and assess factors that may affect survival by using the Canadian HPN Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective analysis of prospectively collected data extracted from the HPN registry, prior to approval of teduglutide in Canada. Using only incident cases, survival probabilities were estimated by using the Kaplan\u2010Meier method for both full\u2010cohort and nonmalignant SBS. Log\u2010rank test was also used to test the differences in survival distributions between subgroups in the univariate analysis. To identify potential variables that are affecting survival distribution of patients for the multivariable analysis, Least Absolute Shrinkage and Selection Operator and stepwise selection procedure were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 321 patients with a known duration receiving HPN (total, 2287 years), of whom 218 were entered into the registry within 1 year of initiation of HPN. Of 218 incident cases, 22 had active malignancy, along with SBS, and their survival time was significantly lower than those with nonmalignant SBS (<jats:italic>P<\/jats:italic>\u2010value &lt; .0001). The 5\u2010year survival of nonmalignant\u2010SBS patients was 81.9%. In this subgroup, there was no significant association between patients\u2019 survival and known intestinal anatomy, age, or sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with nonmalignant SBS who receive HPN have a 5\u2010year survival of &gt;80%. Known intestinal anatomical factors did not affect survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1984","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T05:36:30Z","timestamp":1596346590000},"page":"1083-1088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Survival of Patients With Short\u2010Bowel Syndrome on Home Parenteral Nutrition: A Prospective Cohort Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5826-6229","authenticated-orcid":false,"given":"Jessica","family":"Noelting","sequence":"first","affiliation":[{"name":"Department of Medicine Toronto General Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Gramlich","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton Alberta 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