{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:47:30Z","timestamp":1762782450426,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malnutrition in chronic obstructive pulmonary disease (COPD) patients is more prevalent during times of exacerbation. Fat\u2010free mass index (FFMI), calf circumference (CC), and adductor muscle pollicis thickness (AMPT) can be used to identify reduced muscle mass and have been found to be good predictors of clinical outcomes in other conditions, but they have not been investigated in COPD. Therefore, this study evaluated low muscle mass as predictor of malnutrition, prolonged length of stay (LOS), and in\u2010hospital death in COPD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study was carried out in hospitalized patients with COPD exacerbation. Malnutrition diagnosis was performed by Subjective Global Assessment, and muscle mass was assessed by FFMI, calculated using fat\u2010free mass from bioelectrical impedance, CC, and AMPT. Clinical outcomes (LOS and in\u2010hospital death) were collected from records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy\u2010six patients were included (68.2\u00a0\u00b1\u00a010.4 years old, 56.2% women); 74.2% were classified as Global Initiative of Chronic Obstructive Lung Disease 2 or 3 and 58.2% as malnourished. The median LOS was 11 (7\u201319) days, and the incidence of death was 9.1%. Low FFMI and CC predicted malnutrition (low CC: odds ratio [OR], 4.6; 95% CI, 2.2\u20139.7 and low FFMI: OR, 8.8; 95% CI, 3.7\u201320.8) and were associated with prolonged LOS (low CC: OR, 2.3; 95% CI, 1.1\u20134.6 and low FFMI: OR, 2.5; 95% CI, 1.3\u20134.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simple, inexpensive, and noninvasive parameters of muscle mass\u2014FFMI and CC\u2014are good predictors of malnutrition and prolonged LOS in COPD patients experiencing exacerbation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.1998","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T17:25:00Z","timestamp":1597425900000},"page":"1221-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Low Muscle Mass Is a Predictor of Malnutrition and Prolonged Hospital Stay in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Longitudinal Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-7661","authenticated-orcid":false,"given":"Paula Portal","family":"Teixeira","sequence":"first","affiliation":[{"name":"Federal University of Health Science of Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronnike Hossa","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Federal University of Health Science of Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-7240","authenticated-orcid":false,"given":"Kamila","family":"Valduga","sequence":"additional","affiliation":[{"name":"Endocrine Postgraduation Program of Federal University of Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Esp\u00edndola","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Nutrition Science Postgraduation Program of Federal University of Health Science of Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-5424","authenticated-orcid":false,"given":"Fl\u00e1via Moraes","family":"Silva","sequence":"additional","affiliation":[{"name":"Nutrition Department and Nutrition Science Postgraduation Program in Federal University of Health Science of Porto Alegre  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000356"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2016.1209728"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S174665"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004225"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2015-0021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000395"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2013.10.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.02.66"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2019.28.22.1442"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-015-0068-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718701100108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.12.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12133"},{"issue":"4","key":"e_1_2_10_16_1","first-page":"500","article-title":"Subjective global assessment of nutritional status of chronic obstructive pulmonary disease patients on admission","volume":"14","author":"Gupta B","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1170"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.20960\/nh.1739"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1367942"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.06.017"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615621547"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00070914"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04358"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.03.001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614568155"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200405000-00009"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12049"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.09.024"},{"key":"e_1_2_10_29_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease.Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease.2020. Accessed May 20 2020.https:\/\/goldcopd.org\/wp-content\/uploads\/2019\/11\/GOLD-2020-REPORT-ver1.0wms.pdf"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37562017000000153"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.09.012"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00070914"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.08.012"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.05.031"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.11.006"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.09.014"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.894191"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205960"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.01.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-969OC"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2020.1723452"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.04.007"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.03.002"},{"issue":"1","key":"e_1_2_10_44_1","first-page":"55","article-title":"Malnutrition in chronic kidney failure: what is the best diagnostic method to assess?","volume":"32","author":"Oliveira CMC","year":"2010","journal-title":"J Bras Nefrol"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2016.08.005"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclnm.2010.11.001"},{"issue":"4","key":"e_1_2_10_47_1","first-page":"605","article-title":"The adductor pollicis muscle: a poor predictor of clinical outcome in ICU patients","volume":"24","author":"Leong Shu\u2010Fen C","year":"2015","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20150062"},{"key":"e_1_2_10_49_1","first-page":"490","article-title":"Measurement of the thickness of the adductor pollicis muscle as a predictor of outcome in critically ill patients","volume":"27","author":"Caporossi FS","year":"2012","journal-title":"Nutr Hosp"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102-672020180001e1340"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2017.10.013"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.1998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpen.1998","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpen.1998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:32:07Z","timestamp":1760880727000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jpen.1998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/jpen.1998"],"URL":"https:\/\/doi.org\/10.1002\/jpen.1998","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"2020-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}