{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:50:31Z","timestamp":1776207031976,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early metabolic bone disease (MBD) detection is important in preterm infants to decrease long\u2010term consequence. We aim to explore the early MBD biochemical marker in extremely low\u2010birth\u2010weight (ELBW) infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of 95 preterm infants born in a tertiary care\u2013level neonatal intensive care unit between January 2015 and June 2018, with birth weight &lt;1000\u00a0g. Thirty\u2010five infants were \u201cnothing by mouth\u201d for &gt;14\u00a0days and categorized as the high\u2010risk group; the remaining 60 were categorized as the control group. Mineral intake in the first 14\u00a0days and the trend of serum calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) levels were compared in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Ca and P supplementation in the first 2\u00a0weeks of life were inadequate in both groups. Compared with the control group, significantly lower serum P (mg\/dL) levels were noted in the high\u2010risk group on weeks 2 (3.65 \u00b1 1.2 vs 4.67 \u00b1 1.45; <jats:italic>P<\/jats:italic> &lt; .001), 4 (3.21 \u00b1 0.95 vs 5.83 \u00b1 1.18; <jats:italic>P<\/jats:italic> &lt; .0001), and 6 (3.94 \u00b1 1.1 vs 6.22\u00a0\u00b1 0.78; <jats:italic>P<\/jats:italic> &lt;.0001). There was no significant difference in the serum Ca level, and significantly higher ALP (U\/L) levels were found up until 2\u00a0months of life in the high\u2010risk group (458.36 \u00b1 189.02 vs 335.7 \u00b1 111.51; <jats:italic>P<\/jats:italic> &lt; .014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypophosphatemia developed as early as 2\u00a0weeks old in high\u2010risk preterm infants because of inadequate supplementation. Neither the serum Ca or ALP levels were affected. Thus, the routine monitoring of serum P level should be started 2\u00a0weeks after birth for early MBD detection in extremely ELBW infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2010","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T05:55:22Z","timestamp":1598680522000},"page":"1268-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypophosphatemia as an Early Metabolic Bone Disease Marker in Extremely Low\u2010Birth\u2010Weight Infants After Prolonged Parenteral Nutrition Exposure"],"prefix":"10.1002","volume":"45","author":[{"given":"Yin\u2010Ling","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fu Jen Catholic University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Nien","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Chieh","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010An","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31593-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v5.i3.115"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-47"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2014.06.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.97"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-35-20"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90810-R"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012861"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-23.1.26"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2017.09.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.6.447"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"281","article-title":"Does bone measurement on the radius indicate skeletal status? 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