{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:45:39Z","timestamp":1760921139549,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Short\u2010bowel syndrome is the leading cause of pediatric intestinal failure, resulting in dependency on long\u2010term parenteral nutrition (PN). To promote enteral autonomy in neonates, a key outcome may be intestinal growth in length. The purpose of this study was to determine if intestinal lengthening persists following discontinuation of treatment with 1 of 2 GLP\u20102 analogues with different pharmacokinetic profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Neonatal short\u2010bowel piglets were assigned to saline control (S), 7\u2010day treatment with teduglutide (T) (0.05 mg\/kg twice daily), or 7\u2010day treatment with apraglutide (A) (5 mg\/kg twice weekly). Comparisons were made between day 7 and day 14 endpoints using analysis of variance. Data included small\u2010intestine length, weight, histology, and quantitative polymerase chain reaction analysis of mucosal transcripts for peptide growth factors and their receptors, nutrient transporters, and tight\u2010junction proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with control, 7 days of GLP\u20102 analogue treatment induced mucosal adaptation based on villus hyperplasia (<jats:italic>P<\/jats:italic> = .003), which was not durable 7 days after treatment cessation (day 14; <jats:italic>P<\/jats:italic> = .081). Treatment increased intestinal growth in length by day 7 (<jats:italic>P<\/jats:italic> = .005), which was maintained (by T) or further increased (by A) at day 14 (<jats:italic>P<\/jats:italic> &lt; .001). No significant differences in mucosal transcripts were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unlike mucosal adaptation, intestinal growth appears to be a lasting outcome of treatment with long\u2010acting GLP\u20102 analogues in a neonatal piglet short\u2010bowel model. This has significant clinical implications for neonates, given their potential for intestinal growth. Intestinal lengthening varies between analogues with different half\u2010lives; however, molecular mechanisms require further elucidation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2053","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T23:54:52Z","timestamp":1606348492000},"page":"1466-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Durability of Linear Small\u2010Intestinal Growth Following Treatment Discontinuation of Long\u2010Acting Glucagon\u2010Like Peptide 2 (GLP\u20102) Analogues"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-4137","authenticated-orcid":false,"given":"Tierah","family":"Hinchliffe","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta 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