{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:29:32Z","timestamp":1770460172698,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aspenjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with intestinal failure (IF) receiving home parenteral nutrition (HPN) require long\u2010term central venous catheters (CVCs). Ethanol lock prophylaxis (ELP) can reduce central line\u2013associated bloodstream infections, but there are some concerns of increased breakage rates when used with polyurethane catheters. We reviewed our experience using ethanol locks in both polyurethane and silicone CVCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10\u2010year retrospective study of children with IF receiving HPN that used ELP was conducted. Complications per 1000 catheter days were extracted and a multivariable, mixed\u2010effects Poisson model was used to compare catheter breakage rates and other complications between polyurethane and silicone CVCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 patients were included, comprising 85 CVCs and 13,227 catheter days. The most common cause of IF was necrotizing enterocolitis. Breakages were the most common complication: polyurethane 1.46\/1000 vs silicone 3.76\/1000 catheter days. Silicone catheters had a significantly higher breakage rate (adjusted rate ratio [RR], 2.86; 95% confidence interval [CI], 2.84\u20132.88; <jats:italic>P<\/jats:italic> &lt; .001) whereas polyurethane catheters had higher rates of occlusion (adjusted RR, 0.14; 95% CI, 0.07\u20130.28; <jats:italic>P<\/jats:italic> &lt; .001) and displacements. However, there were no differences in the overall catheter replacement rates and any other catheter\u2010related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with IF receiving long\u2010term HPN, the use of ELP in polyurethane catheters was associated with a lower risk of breakages when compared with silicone CVCs. These results should be regarded as preliminary data, and further studies with a higher number of participants are necessary to provide a better level of evidence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpen.2056","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:19:55Z","timestamp":1607055595000},"page":"1425-1431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prolonged Use of Ethanol Lock Prophylaxis With Polyurethane Catheters in Children With Intestinal Failure: A Single\u2010Center Experience"],"prefix":"10.1002","volume":"45","author":[{"given":"Kathryn","family":"LaRusso","sequence":"first","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery Montreal Children's Hospital, McGill University Health Centre  Montreal Qu\u00e9bec 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